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viernes, 1 de marzo de 2019

The Evolution of MDLC in the Pharmaceutical Industry | Medical News | Medical Articles

	March 1, 2019
	Pharmacy / Pharmacology
	The latest pharmacy / pharmacology news from News Medical

The Evolution of MDLC in the Pharmaceutical Industry

Multi Dimensional Liquid Chromatography (MDLC) is one of the tools that can help to significantly increase analytical efficiency. In this interview Dr Kelly Zhang reviews recent advances in MDLC and describes it as a game changer that will transform the pharmaceutical industry.

Optimizing Biopharmaceutical Manufacturing with Pump Technologies

Over the years, a variety of pump technologies have been tested or used for virus filtration, chromatography, and TFF processes. Lobe and peristaltic pumps are two of the most popular choices of biopharmaceutical manufacturers. However, both have been found to present operational inefficiencies that may render them unsatisfactory for application in the above-mentioned processes.

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Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

In pharmaceutical companies, rats are used commonly in nonclinical studies to investigate the safety, efficacy, and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics.

Screening for Disease Markers Using Non-Invasive Breath Gas Analysis

In this article the methodology by which disease markers can be screened for using non-invasive breath gas analysis is discussed.

	New collaboration aims to prevent life-threatening adverse reactions to medications The University of Arizona College of Medicine - Phoenix and Banner Health are collaborating to prevent life-threatening adverse reactions to medications.

	Promising drug developed to rejuvenate muscle cells Researchers from The University of Texas Medical Branch at Galveston have developed a promising drug that has proven to significantly increase muscle size, strength and metabolic state in aged mice, according to a study just published in Biochemical Pharmacology.

	Researchers identify suicide toxin in the bacteria responsible for tuberculosis The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein. The European team of scientists behind this discovery is coordinated by researchers from the Institute of Pharmacology and Structural Biology and the European Molecular Biology Laboratory.

	Saffron may be a promising herbal alternative for treating ADHD A new short-term pilot study in children and teens 6-17 years old with attention-deficit hyperactivity disorder has shown saffron to be as effective at controlling symptoms as methylphenidate, the commonly prescribed drug Ritalin.

	GC-MS in Biomedicine GC-MS has extensive applications in biomedicine, including disease diagnosis, pharmaceutical quality control, and metabolic profiling.

	Study finds drug interactions in ER's are common but could be prevented In a recent Rutgers study, 38 percent of patients discharged from the emergency department had at least one drug interaction resulting from a newly prescribed medicine.

	Custom-designed proteins may help generate antibodies to inhibit HIV infection A new way to create proteins that can sneak through HIV's protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers.

	Researchers find new precise and accurate biomarker of cyanide exposure Cyanide exposure can happen occupationally or in low levels from inhaling cigarette smoke -- or from being poisoned by someone out to get you.

	Big-data analysis finds new link between popular arthritis drug and heart valve calcification A well-known, four-year study found popular arthritis drug Celebrex no more dangerous for the heart than older drugs in its same classification - commonly called NSAIDs.

	Custom-made proteins could result in antibodies that fight HIV Researchers have developed a new method for the creation of custom-made proteins that can bypass the protective coating of the HIV virus.

	New technique could expedite cancer diagnosis, lead to better patient outcomes The days - or even weeks - spent waiting for the results of a cancer-screening test can feel like an eternity. Especially when early diagnosis and quick action are tied to better outcomes.

	Study: Number of calls to U.S. Poison Control regarding kratom exposure increased In recent years, kratom has become popular as a treatment for chronic or acute pain as well as mood conditions such as depression and anxiety.

	Artificial intelligence can accurately predict prognosis of ovarian cancer patients The artificial intelligence software, created by researchers at Imperial College London and the University of Melbourne, has been able to predict the prognosis of patients with ovarian cancer more accurately than current methods. It can also predict what treatment would be most effective for patients following diagnosis.

	Johns Hopkins scientists find new compound that may prevent reperfusion injury In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke.

	Research finds steep rise in self-poisonings among young people Self-harm from self-poisoning in children and adolescents is not only increasing but starting at a younger age, finds new research by University of Sydney and the NSW Poisons Information Centre.

	Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects The replacement of animals as test subjects is one step closer to reality with the successful testing of multi-organ "human-on-a-chip" models to recapitulate the 28-day experiments typically used in animals to evaluate the systemic toxicity of drug and cosmetic compounds.

	Study doesn’t find enough evidence related to effects of noncaloric sweeteners on gut microbiota The study, carried out by the UGR professor of Biochemistry and Molecular Biology Ángel Gil and his research team, has been published in the scientific journal 'Advances in Nutrition'

	Newly designed molecule could benefit people with Friedrich's Ataxia Skin cells taken from patients with a rare genetic disorder are up to ten times more sensitive to damage from ultraviolet A radiation in laboratory tests, than those from a healthy population, according to new research from the University of Bath.

	News study reanalyzes the effects of noncaloric sweeteners on gut microbiota There is currently not enough evidence related to the effects of noncaloric sweeteners on appetite, short‑term intake, and risk of suffering from cancer or diabetes, as shown by a study recently published in the scientific journal 'Advances in Nutrition'.

	Trump plan to beat HIV hits rough road in rural America One of the goals President Donald Trump announced in his State of the Union address was to stop the spread of HIV in the U.S. within 10 years.

	Once-a-day capsule offers new way to reduce symptoms of chronic breathlessness More than 70,000 Australians who suffer from chronic breathlessness will now have access to life-changing medication to manage their symptoms.

	Activating gene that helps excite neurons reverses depression in male mice Directly activating a gene important to exciting our excitatory neurons and associated with major depression may help turn around classic symptoms like social isolation and loss of interest, at least for males, scientists report.

	What is Major Depressive Disorder? Major depressive disorder (MDD), or ‘clinical depression’, is described as feelings of persistent sadness, worthlessness and hopelessness. It is a serious medical condition which affects the way an individual thinks and behaves, impacting the quality of life and day-to-day function.

	In Florida, drug re-importation from Canada finds new champions, old snags Florida Gov. Ron DeSantis said Wednesday he intends to bring down skyrocketing drug prices by leaning on an existing federal law that could enable the state to import prescription meds wholesale from Canada, where they're much cheaper.

	Researchers discover new mechanism of bone growth In a paper published in the journal Nature, an international research team led by researchers at Karolinska Institutet in Sweden report that bone growth in mice takes place in accordance with the same principles as when new cells are constantly produced in blood, skin and other tissue.

Advances in Dye Development and Microscopy for Live-Cell Super Resolution Microscopy

Advances in Dye Development and Microscopy for Live-Cell Super Resolution Microscopy with the Vutara 352 - Webinars | Bruker

	March 1, 2019
	Fluorescence
	The latest fluorescence news from AZoNetwork

Advances in Dye Development and Microscopy for Live-Cell Super Resolution Microscopy

This webinar discusses Vutara 352 technology and sample preparation techniques for successful live-cell imaging using the currently available family of fluorophores. Additionally, a recent research collaboration involving the development of dyes that spontaneously blink under physiological conditions and low laser power, will be described. The characteristics of these dyes make them ideal for long term live-cell imaging without phototoxicity.

A Light Source in Quantitative Analysis: What Role Does it Play?

Light plays a critical role in our ability to generate high resolution images and to detect in a quantitative manner. The quality of the light required is different for each type of microscopy. Fluorescence is the most demanding in the sense that it's not a particularly efficient process, so you have to put in billions of photons in order to get out enough to visualize something.

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Novel Imaging Methods for Biomedicine

Wei Min has been awarded the Pittcon 2019 Achievement Award. In this interview, he outlines the current imaging challenges in biomedicine and how his novel chemical imaging methods can overcome these.

Immunofluorescence Methods for IHC

Fluorescent detection (immunofluorescence) methods use fluorochrome labels, which emit light of a longer wavelength when excited by light of a specific wavelength.

	Avoiding Cell Death in Fluorescence Microscopy It is important to prevent cell death during fluorescence microscopy, as dying cells may skew experimental results and introduce artifacts.

	New method detects potentially disease-causing forms of proteins using fluorescence A new method uses fluorescence to detect potentially disease-causing forms of proteins as they unravel due to stress or mutations.

	Choosing the Best Fusion Flux for XRF Sample Preparation This article discusses how to choose the best fusion flux for XRF sample preparation.

	Analysis of Gemstones Using EDXRF for Determination of Origin and Authenticity Energy Dispersive X-Ray Fluorescence (EDXRF) is a key instrument to determine the authenticity of precious gemstones and their geographical origin.

	Novel ratiometric fluorescent probe for studying cellular activity of anticancer drug NUS chemists have developed a novel ratiometric fluorescent probe for studying cellular activity of the clinically important anticancer drug cisplatin for next generation drug development.