Würzburg researchers discover alternative approach to preventing thrombosis

https://www.news-medical.net/news/20260814/Wurzburg-researchers-discover-alternative-approach-to-preventing-thrombosis.aspx Glycoprotein VI, or GPVI for short, is a surface receptor found exclusively on platelets and their precursor cells, megakaryocytes in the bone marrow. GPVI is primarily responsible for binding collagen at the site of an injured blood vessel, which triggers the activation and aggregation of platelets. GPVI therefore has a role in so-called hemostasis, the process of stopping bleeding. However, excessive activation of the GPVI receptor can lead to the formation of pathological thrombi and thus to vascular occlusions, which impede blood flow to vital organs. A heart attack or stroke may result.