Why sex matters in preclinical research Researchers are moving beyond the male default as evidence reveals how sex influences disease, drug response, and clinical outcomes. Written byBree Foster, PhD

https://www.drugdiscoverynews.com/why-sex-matters-in-preclinical-research-17414?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9TdlujUHWvZbgq7TOznYNIOrYBWeQ8b6lMX8xMGaH_-qok4RxlDZIdW2nRlvPACUCdOCJGoPTnYec-H5Ia104FlI9CbA&_hsmi=432376485&utm_content=432376485&utm_source=hs_email Healthcare should be tailored to everyone, yet for decades medical research has largely overlooked half of the global population. From the earliest stages of drug discovery, researchers have frequently relied on male cells, male animals, and predominantly male clinical trial populations — with female biology often treated as a complicating factor rather than a fundamental component of human physiology.