Wake-activated brain circuits reveal what drives the urge to sleep

https://www.news-medical.net/news/20260820/Wake-activated-brain-circuits-reveal-what-drives-the-urge-to-sleep.aspx By mapping the brain during prolonged wakefulness, researchers pinpointed neuronal populations whose activity rises with time awake and tested how strongly they shape the pressure to sleep. In a recent study published in the journal Nature, researchers conducted comprehensive whole-brain activity mapping and targeted circuit manipulations in mice to elucidate the poorly understood neural mechanisms governing homeostatic sleep drive.