Fact or Fiction: Multiple Sclerosis Diagnosis and Workup Reviewed by Christopher C. Luzzio, MD

https://reference.medscape.com/viewarticle/fact-or-fiction-multiple-sclerosis-diagnosis-and-workup-2026a1000nsr?src=&_gl=1*667rps*_gcl_aw*R0NMLjE3ODM4NzAxMzguQ2p3S0NBanc5c3pTQmhCTkVpd0FDNTdTcTJZUXZTZkkxc01raEZQZ1VLSWRQZkVUdGU4U212WEI0NGh3aEE5WmMtVDhTSVBEWlBzNmdSb0NiT1FRQXZEX0J3RQ..*_gcl_au*NjkzMDY5MjIxLjE3ODA2NzA2MDAuMTY4MzI1MDM3LjE3ODY5NzI2OTIuMTc4Njk3NDg1Mi4yMTI0OTM5ODg4LjE3ODY4OTIyNTQuMTc4Njk3NDg1Mg.. The 2024 revision of the McDonald criteria has substantially refined how clinicians diagnose multiple sclerosis (MS), placing greater emphasis on robust imaging and cerebrospinal fluid (CSF)-based evidence. The updated framework incorporates new MRI biomarkers, revised CSF parameters, and tailored guidance for specific patient subgroups, such as individuals with radiologically isolated syndrome (RIS) and older adults.