Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France - Volume 26, Number 6—June 2020 - Emerging Infectious Diseases journal - CDC

Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France - Volume 26, Number 6—June 2020 - Emerging Infectious Diseases journal - CDC

Volume 26, Number 6—June 2020

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Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

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Christophe Rodriguez , Guillaume Gricourt1, Melissa Ndebi1, Vanessa Demontant, Lila Poiteau, Sonia Burrel, David Boutolleau, Paul-Louis Woerther, Vincent Calvez, Sebastian Stroer, and Jean-Michel Pawlotsky

Author affiliations: Henri Mondor Hospital, Assistance Publique des Hôpitaux de Paris at University of Paris-Est, Créteil, France (C. Rodriguez, G. Gricourt, M. Ndebi, V. Demontant, L. Poiteau, P.-L. Woerther, J.-M. Pawlotsky); Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris at Sorbonne-Université, Paris, France (S. Burrel, D. Boutolleau, V. Calvez, S. Stroer)

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Abstract

We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France.