Genetic Cancer Risk Assessment: A Screenshot of the Psychosocial Profile of Women at Risk for Hereditary Breast and Ovarian Cancer Syndrome

Natalia Campacci 1, Henrique de Campos Reis Galvão 2, Lucas França Garcia 3, Paula Carvalho Ribeiro 2, Rebeca Silveira Grasel 1, José Roberto Goldim 4, Patrícia Ashton-Prolla 4, Edenir Inêz Palmero 1 5

Affiliations

PMID: 31984583
DOI: 10.1002/pon.5305

Abstract

Objective: There is a lack of information describing Brazilian women at risk of hereditary breast and ovarian cancer syndrome (HBOC) who undergo genetic cancer risk assessment (GCRA). This study aims to characterize the psychosocial profile of women at risk for HBOC at their first GCRA to obtain an overview of their families' profiles and the challenges of the oncogenetics setting.

Methods: This was a cross-sectional study in which interviews were conducted with 83 cancer-affected women at their first GRCA appointment after the pedigree draw. Tools to evaluate psychological outcomes were applied. The pedigree genogram and ecomap were constructed and analyzed with content analysis using the "life course perspective" theory.

Results: Individuals perceived their breast/ovarian cancer risk to be equal to that of the general population, although they were highly concerned about developing cancer. No evidence of anxiety or depressive symptoms was identified. Participants used the coping strategy of searching for religiosity. The genograms and ecomaps resulted in five major themes: support and social support; attitudes, feelings and emotions; cancer causes; communication; and relationships with relatives. Individuals between 20-29 years of age and those with no family history of cancer tended not to communicate with relatives, which may indicate future problems in the GCRA process regarding genetic testing.

Conclusion: This study demonstrated that knowing the families who undergo the GCRA process can help professionals provide more individualized and thorough attention during GCRA and genetic testing, which results in better follow-up and prevention strategies. This article is protected by copyright. All rights reserved.

Keywords: cancer; genetic cancer risk assessment; genogram; hereditary breast and ovarian cancer; oncology.