Precision Medicine and Targeted Therapies in Breast Cancer.

Author information

1: University Hospitals Cleveland Medical Center, MetroHealth Hospitals, Louis Stokes Veterans Administration Hospital, Case Western Reserve University, Cleveland, OH, USA.
2: Case Western Reserve University, Cleveland, OH, USA.
3: MetroHealth System, Case Western Reserve University, Cancer Care Pavilion, Suite C2100, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, USA. Electronic address: bli@metrohealth.org.

Abstract

Precision medicine and targeted therapies have a long history in the treatment of breast cancer and continue to show promise for further specialized and individualized care for this disease. From the discovery of endocrine and HER2 targeted therapies, to multigene arrays in chemotherapy for more specific patient selection, to radiomics and genetic subtyping, targeted therapies and precision medicine continue to push the management of breast cancer toward more individualized care. This article describes the foundation and future of targeted therapy and precision medicine in breast cancer.