Gynecol Oncol. 2019 Feb 1. pii: S0090-8258(19)30062-9. doi: 10.1016/j.ygyno.2019.01.019. [Epub ahead of print]
A patient-centered mobile health application to motivate use of genetic counseling among women with ovarian cancer: A pilot randomized controlled trial.
Vogel RI1, Niendorf K2, Petzel S1, Lee H1, Teoh D1, Blaes AH3, Argenta P1, Rivard C1, Winterhoff B1, Lee HY4, Geller MA5.
Despite current guidelines recommending women with ovarian cancer receive genetic risk evaluation by a genetic counselor, utilization has historically been low. We sought to assess the feasibility and effectiveness of a week-long mobile Application for GeneticInformation on Cancer (mAGIC) intervention aimed to persuade women with ovarian cancer to pursue genetic counseling.
The mobile application intervention was based on the Fogg Behavior Model, and consisted of three parts: (1) identifying barriers, (2) developing motivators, and (3) providing triggers to action. The Health Belief Model was used to guide content development. We conducted a prospective, randomized, controlled pilot trial among 104 untested women with a history of epithelial ovarian, primary peritoneal or fallopian tube cancer with the primary objective of increasing uptake of cancer genetic counseling services.
Utilization of cancer genetic counseling services improved in both study arms over historical controls, however there was no statistically significant difference between them (intervention: 54.5% versus control: 38.6%; p = 0.14). However, compared to controls, women randomized to the mAGIC intervention demonstrated greater knowledge of hereditary cancer (0-10 scale; 9.4 ± 1.0 vs. 7.1 ± 1.5; p < 0.0001), which persisted for at least three months. Additionally, 96% of women in the intervention group reported they had talked with their family about genetic counseling compared to 77% in the control group (p = 0.01).
The mAGIC intervention did not result in increased uptake of genetic counseling, however it provided significant secondary benefits, including increased participants' knowledge about hereditary ovarian cancer, self-efficacy, and their reported communication with family members. ClinicalTrials.gov Identifier: NCT02877862.
Copyright © 2019. Published by Elsevier Inc.
BRCA; Communication; Genetic counseling; Mobile application; Ovarian cancer