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The biological functions of DNA: from the sublime to the slime | Arthritis Research & Therapy | Full Text

The biological functions of DNA: from the sublime to the slime | Arthritis Research & Therapy | Full Text

Reflections of a rheumatologist

Arthritis Research & Therapy




The biological functions of DNA: from the sublime to the slime

Arthritis Research & Therapy201719:275
Published: 15 December 2017

Keywords

DNABiofilmsBacteriaAnti-DNALupusToll-like receptorCell deathAmyloid
Of all the molecules in nature, DNA is the most exalted. The blueprint of life, DNA bears the genetic code inscribed in the famous double helix. The structure of DNA is elegant, magisterial, even sublime. In the conceptualization of DNA’s role in biology, two overarching ideas have long dominated. First, DNA is an informational macromolecule. Second, DNA’s locus of action is intracellular. In the past decades, this conceptualization has undergone a paradigm shift that has left many investigators positively shaking.

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