Reflections of a rheumatologistArthritis Research & Therapy
The biological functions of DNA: from the sublime to the slime
Arthritis Research & Therapy201719:275
© The Author(s). 2018
Published: 15 December 2017
DNABiofilmsBacteriaAnti-DNALupusToll-like receptorCell deathAmyloid
Of all the molecules in nature, DNA is the most exalted. The blueprint of life, DNA bears the genetic code inscribed in the famous double helix. The structure of DNA is elegant, magisterial, even sublime. In the conceptualization of DNA’s role in biology, two overarching ideas have long dominated. First, DNA is an informational macromolecule. Second, DNA’s locus of action is intracellular. In the past decades, this conceptualization has undergone a paradigm shift that has left many investigators positively shaking.