Stem Cell Research & Therapy
Alzheimer’s disease, dementia, and stem cell therapy
Stem Cell Research & Therapy20178:111
© The Author(s). 2017
Published: 12 May 2017
Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.
Alzheimer’s diseaseEmbryonic stem cellsInduced pluripotent stem cellsMesenchymal stem cellsNeural stem cells