Leicester research could help identify people with asthma of different severities
Research can help to identify people with mild asthma from those with moderate or severe asthma
A team of researchers from the NIHR Leicester Biomedical Research Centre – a partnership between Leicester’s Hospitals, the University of Leicester and Loughborough University - has identified biological variations in lung tissue samples that for the first time can help identify people with mild asthma from those with moderate or severe asthma.
The team led by Professors Salman Siddiqui and Peter Bradding used state-of-the-art statistical methods involving visualization approaches, to perform the largest comprehensive analysis of common pathological features in the airways of people with asthma of different severities. They also investigated the clinical features of these subtypes and whether there is any association with changes in genes and decline in lung function.
Professor Siddiqui and his team identified multiple biological ‘micro-clusters’ which means that there are different combinations of active genes in each of the reported subtypes of asthma.
Professor Bradding, who is a Professor of Respiratory Medicine at the University of Leicester and Consultant Respiratory Physician at Leicester’s Hospitals, said:
Professor Siddiqui, Professor of Airway Diseases at the University of Leicester and Consultant Respiratory Physician at Leicester’s Hospitals, added:
Dr Samantha Walker, Director of Research and Policy at Asthma UK, which funded the study, said:
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