domingo, 18 de marzo de 2018

Genomic Testing in Lung Cancer: Past, Present, and Future. - PubMed - NCBI

Genomic Testing in Lung Cancer: Past, Present, and Future. - PubMed - NCBI



 2018 Mar;16(3):323-334. doi: 10.6004/jnccn.2017.7019.

Genomic Testing in Lung Cancer: Past, Present, and Future.

Abstract

Precision medicine commonly refers to the selection of the most effective cancer treatments based on the presence of specific biomarkers (eg, genomic abnormalities) in a patient's tumor. Therefore, genomic testing is used to identify patients whose tumors harbor the vulnerability that is sensitive to corresponding targeted therapies. This approach allows for the selection of patients who have the greatest chance of deriving benefit from the treatments, reduces toxicity, and significantly improves outcome; precision medicine is recommended for advanced non-small cell lung cancer. This article reviews the evolution of genomic testing in lung cancer, from its development, including first success and failures, to its current use in the care of patients with lung cancer, and addresses future considerations, such as the expected increase of targetable abnormalities, the need to follow the genomic profile over time, and tumor heterogeneity.

PMID:
 
29523671
 
DOI:
 
10.6004/jnccn.2017.7019

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