domingo, 4 de febrero de 2018

Clinical study of hereditary ovarian cancer syndrome in Shandong province, East China. - PubMed - NCBI

Clinical study of hereditary ovarian cancer syndrome in Shandong province, East China. - PubMed - NCBI



 2018 Jan 23. doi: 10.1002/ijgo.12447. [Epub ahead of print]

Clinical study of hereditary ovarian cancer syndrome in Shandong province, East China.

Sheng X1Zhong Y2Lu C1Peng J1Yu H1Guo J1,3.

Abstract

OBJECTIVE:

To explore the clinicopathologic characteristics and prognosis of hereditary ovarian cancer syndrome (HOCS) in Shandong province, East China.

METHODS:

The present retrospective study assessed the clinicopathologic characteristics and prognosis among patients with HOCS treated at Shandong Cancer Hospital, China, between January 1, 2008, and January 31, 2016. Data from women with primary ovarian cancer who met HOCS diagnostic criteria (genetic-disease group) were compared with data from a control group of 100 women with sporadic ovarian cancer (sporadic-disease group) identified using simple random sampling.

RESULTS:

Among 1247 records of primary ovarian cancer during the study period, 96 (7.7%) women from 77 pedigrees had HOCS (genetic-disease group), and 65 of these pedigrees had sufficient data available for inclusion. In the genetic-disease group, 55 (85%) and 10 (15%) women inherited the disease through the maternal and paternal lines, respectively. Age of onset was earlier in the genetic-disease group compared with the sporadic-disease group (P=0.016), the proportion of mucinous adenocarcinoma was lower in the genetic-disease group (P=0.006), and the genetic-disease group had higher 3-year (P=0.036) and 5-year (P=0.035) survival rates.

CONCLUSION:

HOCS exhibited maternal lineage primarily, and featured an early age of onset, advanced disease (stage III), serous adenocarcinoma, and a better prognosis after comprehensive treatment (including surgery, chemotherapy, and occasionally radiotherapy) relative to sporadic ovarian cancer. This article is protected by copyright. All rights reserved.

KEYWORDS:

Diagnosis and treatment; Genetic counseling; Hereditary ovarian cancer; Prognosis

PMID:
 
29359324
 
DOI:
 
10.1002/ijgo.12447

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