viernes, 17 de marzo de 2017

The interplay between the host and HSV-1 infection

The interplay between the host and HSV-1 infection

Biomed Central

Virology Journal


The interplay between the host and HSV-1 infection

Edited by Chunfu Zheng
Herpes simplex virus type 1 (HSV-1) is a typical human-restricted pathogen, which is carried by 50-90% of the population worldwide, with higher frequencies in developing countries. HSV-1 is well known for its ability to establish a lifelong latent infection in neurons and trigger reactivation and lytic infection, mainly in epithelial or mucosal cells.
Although HSV-1 was identified over 100 years ago, the battle between HSV-1 and the host continues, as there is no vaccine yet available, and HSV-1 is still one of the major infectious diseases worldwide.
This thematic series, published in Virology Journal, is to help us not only improve our knowledge of virus-host interactions but also develop novel antiviral approaches and vaccines against HSV-1 infection.

    Visualizing the replicating HSV-1 virus using STED super-resolution microscopy

    Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...
    Zhuoran Li, Ce Fang, Yuanyuan Su, Hongmei Liu, Fengchao Lang, Xin Li, Guijun Chen, Danfeng Lu and Jumin Zhou
    Virology Journal 2016 13:65
    Published on: 9 April 2016

    Evasion of host antiviral innate immunity by HSV-1, an update

    Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...
    Chenhe Su, Guoqing Zhan and Chunfu Zheng
    Virology Journal 2016 13:38
    Published on: 8 March 2016

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