Virology Journal
The interplay between the host and HSV-1 infection
Edited by Chunfu Zheng
Herpes simplex virus type 1 (HSV-1) is a typical human-restricted pathogen, which is carried by 50-90% of the population worldwide, with higher frequencies in developing countries. HSV-1 is well known for its ability to establish a lifelong latent infection in neurons and trigger reactivation and lytic infection, mainly in epithelial or mucosal cells.
Although HSV-1 was identified over 100 years ago, the battle between HSV-1 and the host continues, as there is no vaccine yet available, and HSV-1 is still one of the major infectious diseases worldwide.
This thematic series, published in Virology Journal, is to help us not only improve our knowledge of virus-host interactions but also develop novel antiviral approaches and vaccines against HSV-1 infection.
- RESEARCH
Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions
Herpes simplex virus type 1 (HSV1), a member of the alphaherpesvirinae, can cause recurrent facial lesions and encephalitis. Two membrane envelopment processes, one at the inner nuclear membrane and a second a...Virology Journal 2016 13:175Published on: 20 October 2016 - RESEARCH
HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway
HSV-2 is the major cause of genital herpes. We previously demonstrated that the host viral restriction factor tetherin restricts HSV-2 release and is antagonized by several HSV-2 glycoproteins. However, the me...Virology Journal 2016 13:154Published on: 15 September 2016 - RESEARCH
Functional prediction of differentially expressed lncRNAs in HSV-1 infected human foreskin fibroblasts
One of the most important functions of long noncoding RNAs (lncRNAs) is to control protein coding gene transcription by acting locally in cis, or remotely in trans. Herpes Simplex Virus type I (HSV-1) latently...Virology Journal 2016 13:137Published on: 5 August 2016 - REVIEW
HSV-1 tegument protein and the development of its genome editing technology
Herpes simplex virus 1 (HSV-1) is composed of complex structures primarily characterized by four elements: the nucleus, capsid, tegument and envelope. The tegument is an important viral component mainly distri...Virology Journal 2016 13:108Published on: 24 June 2016 - REVIEW
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways
Human herpes simplex virus (HSV) is a ubiquitous human pathogen that establishes a lifelong latent infection and is associated with mucocutaneous lesions. In multicellular organisms, cell death is a crucial ho...Virology Journal 2016 13:77Published on: 6 May 2016 - RESEARCH
Visualizing the replicating HSV-1 virus using STED super-resolution microscopy
Replication of viral genome is the central event during the lytic infectious cycle of herpes simplex virus 1 (HSV-1). However, the details of HSV-1 replication process are still elusive due to the limitations ...Virology Journal 2016 13:65Published on: 9 April 2016 - REVIEW
Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire
Extracellular vesicles are defined as a heterogeneous group of vesicles that are released by prokaryotic to higher eukaryotic cells and by plant cells in an evolutionary conserved manner. The significance of t...Virology Journal 2016 13:63Published on: 5 April 2016 - REVIEW
Role of ND10 nuclear bodies in the chromatin repression of HSV-1
Herpes simplex virus (HSV) is a neurotropic virus that establishes lifelong latent infection in human ganglion sensory neurons. This unique life cycle necessitates an intimate relation between the host defense...Virology Journal 2016 13:62Published on: 5 April 2016 - REVIEW
Evasion of host antiviral innate immunity by HSV-1, an update
Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran...Virology Journal 2016 13:38Published on: 8 March 2016
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