Personalized Medicine in Respiratory Disease: Role of Proteomics.

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Abstract

Respiratory diseases affect humanity globally, with chronic lung diseases (e.g., asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, among others) and lung cancer causing extensive morbidity and mortality. These conditions are highly heterogeneous and require an early diagnosis. However, initial symptoms are nonspecific, and the clinical diagnosis is made late frequently. Over the last few years, personalized medicine has emerged as a medical care approach that uses novel technology aiming to personalize treatments according to the particular patient's medical needs. This review highlights the contributions of proteomics toward the understanding of personalized medicine in respiratory disease and its potential applications in the clinic.

KEYWORDS:

AERD; Asthma; COPD; Cystic fibrosis; Idiopathic pulmonary fibrosis; LC–MS; Lung cancer; Mass spectrometry; Personalized medicine; Protein biomarker; Respiratory disease; Respiratory proteomics