Nature Reviews Neurology

Volume 13, No 2 February 2017

ALSO THIS MONTH

CONFERENCES

For the neurology conference calendar for the coming months, click here.

CURRENT ISSUE

Review

The psychosis spectrum in Parkinson disease

Dominic H. ffytche, Byron Creese, Marios Politis, K. Ray Chaudhuri, Daniel Weintraub, Clive Ballard & Dag Aarsland

The publication of a consensus definition of Parkinson disease (PD) psychosis in 2007 led to a rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. The authors discuss the evolving view of PD psychosis, from distinct classes of symptoms to a continuum progressing over the course of PD.

CURRENT ISSUE

Year in Review

CNS Infections in 2016: 2016, the year of Zika virus

Diederik van de Beek & Matthijs C. Brouwer

In 2016, the literature on neurological infections was, understandably, dominated by Zika virus. However, we should not overlook important publications on the treatment of cryptococcal and bacterial meningitis.

CURRENT ISSUE

Review

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

Ammar Al-Chalabi, Leonard H. van den Berg & Jan Veldink

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. Here, the authors outline previous and current efforts to characterize genes that are associated with ALS, and describe what is currently known about the genetic architecture of ALS.

CURRENT ISSUE

Research Highlights

Alzheimer disease Soluble TREM2 in CSF sheds light on microglial activation in AD

Parkinson disease Could gut microbiota influence severity of Parkinson disease?

Motor neuron disease Nusinersen potentially effective in SMA

Neuroimmunology Could antibodies cause psychosis?

NOTICEBOARD

Expert consensus document: The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative

The central vein sign (CVS) has been proposed as a novel MRI biomarker to improve the accuracy and speed of multiple sclerosis (MS) diagnosis. This Consensus Statement from the NAIMS Cooperative provides a roadmap to help radiologists and neurologists to better understand, refine, standardize and evaluate the CVS in the diagnosis of MS.

Key Advances in Medicine

The Key Advances in Medicine eBook is bursting with information for medical students, physicians and clinical researchers wishing to keep up with the most significant medical breakthroughs of the past year. This eBook, which is free to download for registered users, contains 44 articles summarizing the key clinical and biomedical studies published in 2015 and highlighting the trends to watch out for in 2016.

A Decade in Medicine

The past 10 years have seen great advances in the understanding and treatment of human disease. For expert perspectives on the most important breakthroughs, don't miss the FREE A Decade in Medicine eBook. In this special collection of 47 articles, commissioned to celebrate the 10^th anniversary of the launch of the clinical Nature Reviews journals, leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields.

10^th Anniversary

In November 2015, Nature Reviews Neurology (originally published as Nature Clinical Practice Neurology) celebrates 10 years since the launch of the journal. To mark this occasion, we present an anniversary issue containing specially commissioned articles that highlight progress in neurology over the past decade and outline the research priorities for the next 10 years.

Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—establishing disease prognosis and monitoring patients

Mike P. Wattjes, Àlex Rovira, David Miller, Tarek A. Yousry, Maria P. Sormani, Nicola de Stefano, Mar Tintoré, Cristina Auger, Carmen Tur, Massimo Filippi, Maria A. Rocca, Franz Fazekas, Ludwig Kappos, Chris Polman, Frederik Barkhof & Xavier Montalban; on behalf of the MAGNIMS study group

The second part of the MAGNIMS network's evidence-based guidelines focuses on the use of MRI in prognostication and follow-up in patients with multiple sclerosis. The group recommends several techniques for monitoring disease activity and treatment efficacy.

Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

The use of MRI in patients with multiple sclerosis (MS) is commonplace in clinical settings. However, the precise implementation of MRI in the diagnosis of MS is highly variable, which is problematic in the context of the substantial technical advances of the past decade. In these Evidence-Based Guidelines, members of the MAGNIMS study group present a standardized approach to the use of MRI in the diagnosis of MS.

Expert Consensus Document: Mind the gaps—advancing research into short–term and long–term neuropsychological outcomes of youth sports–related concussions

Sports-related concussion is increasingly recognized as a potential danger to paediatric populations, but its short–term and long-term consequences remain poorly understood. This Expert Consensus Document is the result of a 1-day meeting convened by Safe Kids Worldwide, the Alzheimer's Drug Discovery Foundation, and the Andrews Institute for Orthopaedics and Sports Medicine, with the aim of highlighting knowledge gaps and areas of critically needed research in youth sports-related concussion.

Nature Reviews Disease Primers

The latest Nature Reviews title is an online–only journal that publishes broad overview articles—called Primers—on diseases and disorders across all medical specialties. This scope includes 'classic' diseases, as well as consequences of ageing, behavioural conditions, developmental disorders and nutritional deficiencies — all of which have important consequences for human health. Primers have a modular structure, covering epidemiology; disease mechanisms; diagnosis, screening and prevention; management; and quality of life. Authored by an international panel of academic scientists, translational researchers and clinicians, new Primers will be published each week.

Focus: Epilepsy

Treatment-resistant epilepsy remains a major burden at both global and individual levels. In this special focus issue on epilepsy, cutting-edge investigators from around the world highlight the important challenges and progress in epilepsy research and clinical practice.
Produced with financial support from UCB