Methylation of gene panel may help predict breast CA survival

Methylation of gene panel may help predict breast CA survival

Kala Visvanathan, M.B.B.S., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues used a new quantitative multiplex assay to predict survival outcomes in MBC. Ten genes were tested in duplicate serum samples at baseline, week four, and first restaging for 141 women. On the basis of six of the 10 genes, a cumulative methylation index (CMI) was generated, and correlations with progression-free survival (PFS), overall survival (OS), and disease status at first restaging were assessed.