ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.

Gupta AK1, Kaur K1, Rajput A1, Dhanda SK1, Sehgal M1, Khan MS1, Monga I1, Dar SA1, Singh S1, Nagpal G1, Usmani SS1, Thakur A1, Kaur G1, Sharma S1, Bhardwaj A1, Qureshi A1, Raghava GP1, Kumar M1.

Author information

Abstract

Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health Organization (WHO). It causes Zika fever and illness ranging from severe autoimmune to neurological complications in humans. To facilitate research on this virus, we have developed an integrative multi-omics platform; ZikaVR (http://bioinfo.imtech.res.in/manojk/zikavr/), dedicated to the ZIKV genomic, proteomic and therapeutic knowledge. It comprises of whole genome sequences, their respective functional information regarding proteins, genes, and structural content. Additionally, it also delivers sophisticated analysis such as whole-genome alignments, conservation and variation, CpG islands, codon context, usage bias and phylogenetic inferences at whole genome and proteome level with user-friendly visual environment. Further, glycosylation sites and molecular diagnostic primers were also analyzed. Most importantly, we also proposed potential therapeutically imperative constituents namely vaccine epitopes, siRNAs, miRNAs, sgRNAs and repurposing drug candidates.

PMID:: 27633273
PMCID:: PMC5025660
DOI:: 10.1038/srep32713

[PubMed - in process]

Free PMC Article

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ZIKA VIRUS

Last Updated: Nov 01, 2016

What You Need to Know
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