Added text to state that the International Myeloma Working Group (IMWG) evaluated 4,445 patients to create a Revised International Staging System incorporating lactate dehydrogenase levels and interphase flourescence in situ hybridization results (cited Palumbo et al. as reference 2).
Revised statistics about criteria and median survival data in stages I, II, and III multiple myeloma in the International Staging System for Multiple Myeloma table.
Added text to the criteria about creatinine that was published by the IMWG to identify patients with active myeloma who require therapy, stating that myeloma can cause renal dysfunction via hypercalcemia, amyloidosis, or light chain deposition disease (cited Sayed et al. as reference 6).
Added text to state that between 2007 and 2012, the International Blood and Marrow Transplant Research Program identified 800 patients with amyloidosis who underwent autologous stem cell transplantation; the 5-year overall survival (OS) was 77% and transplant-related mortality was 5%, suggesting better selection of patients for transplantation (cited D'Souza et al. as reference 19 and level of evidence 3iiiA).
Added text about several phase I and phase II trials that evaluated the CD38 targeting monoclonal antibody daratumumab as a single agent for relapsed or refractory multiple myeloma (cited Usmani et al. as reference 72). Also revised statistics about median follow-up, overall response rate, and minimal response data.
Added text to state that triplets including either melphalan or cyclophosphamide combined with lenalidomide and dexamethasone were compared with a doublet of lenalidomide and dexamethasone in 662 patients; there were no differences in outcome for progression-free survival or OS, but the doublet showed less toxicity (cited Magarotto et al. as reference 96).
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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