domingo, 6 de noviembre de 2016

Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes. - PubMed - NCBI

Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes. - PubMed - NCBI

 2016 Oct 21. doi: 10.1111/nyas.13257. [Epub ahead of print]

Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes.

Abstract

Microbial communities contain diverse bacteria that play important roles in every environment. Advances in sequencing and computational methodologies over the past decades have illuminated the phylogenetic and functional diversity of microbial communities from diverse habitats. Among the activities encoded in microbiomes are the abilities to synthesize and resist small molecules, yielding antimicrobial activity. These functions are of particular interest when viewed in light of the public health emergency posed by the increase in clinical antimicrobial resistance and the dwindling antimicrobial discovery and approval pipeline, and given the intimate ecological and evolutionary relationship between antimicrobial biosynthesis and resistance. Here, we review genomic and functional methods that have been developed for accessing the antimicrobial biosynthesis and resistance capacity of microbiomes and highlight outstanding examples of their applications.

KEYWORDS:

antimicrobial resistance; antimicrobials; metagenomics; microbiome

PMID:
 
27768825
 
DOI:
 
10.1111/nyas.13257

[PubMed - as supplied by publisher]


Public Health Genomics Knowledge Base (v1.2)

Genomics & Health Impact Update banner with DNA in background

 micro cells

MICROBIOME




Last Updated: Nov 02, 2016

CDC Resources with and image of DNA

Seletced Insights & Reviews with various images of researchers in labortory environments

Epidemiology with an image of a crowd of people with a double helix

Translational Research with two images of people talking to a genetic counselor and an image of a hand with wrapped sequecing around it

Evidence Synthesis with an image of sequencing and a double helix

Practice & Implementation with images of people taking to a doctor and a nurse examining a child

Relevant Resources

No hay comentarios:

Publicar un comentario