Advanced Molecular Detection of Malarone Resistance. - PubMed - NCBI

Advanced Molecular Detection of Malarone Resistance. - PubMed - NCBI

Antimicrob Agents Chemother. 2016 May 23;60(6):3821-3. doi: 10.1128/AAC.00171-16. Print 2016 Jun.

Advanced Molecular Detection of Malarone Resistance.

Talundzic E1, Plucinski MM2, Biliya S3, Silva-Flannery LM4, Arguin PM5, Halsey ES2, Barnwell JW5, Vannberg F3, Udhayakumar V5.

Author information

Abstract

The rapid emergence of drug-resistant malaria parasites during the course of an infection remains a major challenge for providing accurate treatment guidelines. This is particularly important in cases of malaria treatment failure. Using a previously well-characterized case of malaria treatment failure, we show the utility of using next-generation sequencing for early detection of the rise and selection of a previously reported atovaquone-proguanil (malarone) drug resistance-associated mutation.

Copyright © 2016, American Society for Microbiology. All Rights Reserved.

PMID:

 

27001821

 

PMCID:

 

PMC4879379

 [Available on 2016-12-01]

 

DOI:

 

10.1128/AAC.00171-16

[PubMed - in process]

Public Health Genomics Knowledge Base (v1.2)

Last Posted: Nov-04-2016 2PM

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