jueves, 7 de julio de 2016

NCTR Publications > NCTR Research Highlights

NCTR Publications > NCTR Research Highlights

National Center for Toxicological Researh log with FDA on left side

Current Highlight from July 1, 2016

Dietary Influences on Toxicology Study Outcomes   
NCTR's dietary studies suggest that subclinical micronutrient deficiencies could impact the results of toxicology studies. Additionally, the role of subclinical micronutrient deficiencies in reproductive deficits in animals and humans may warrant attention. A range of endpoints typically evaluated in general and reproductive toxicity studies were evaluated in mice fed a series of natural and purified ingredient diets with variable levels of soy protein and soy isoflavones. Significant differences in endpoints such as body weight, insulin, and glucose blood levels, and time to first estrus were observed among diet groups. A deficit in sperm production in one diet group appeared to be related to an unanticipated micronutrient deficiency, and this effect on spermatogenesis was observed in the absence of other significant clinical signs. Diet selection for toxicology testing should be considered, complete formulations should be reported, and evaluations for the level of nutrients should be tested to enhance the interpretability of study results. A manuscript detailing the study is available at Food and Chemical Toxicology.disclaimer icon

For additional information, please contact Barry Delclos, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.

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