lunes, 23 de mayo de 2016

Genetics of Skin Cancer (PDQ®)—Health Professional Version - National Cancer Institute

Genetics of Skin Cancer (PDQ®)—Health Professional Version - National Cancer Institute

National Cancer Institute

Genetics of Skin Cancer (PDQ®)–Health Professional Version


Changes to This Summary (05/19/2016)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Updated National Comprehensive Cancer Network as reference 158.
Added text to state that a Swedish study of 224 melanoma index cases and 944 of their first-degree relatives from 154 CDKN2A wild-type families and 11,680 matched controls showed that personal and family histories of melanoma increased the risk of SCC, with relative risks of 9.1 for personal history and 3.4 for family history (cited Helgadottir et al. as reference 56).
Revised text to state that mutations in CDKN2A account for 35% to 40% of familial melanomas and fewer than 1% of unselected melanoma cases (cited Aoude et al. as reference 82).
Added text to state that targeted sequencing found only seven germline missense mutations in 1,109 unselected cutaneous melanoma cases.
Added text to state that a predictive model that uses clinical criteria to estimate the probability of a PTEN mutation is available; a cost-effectiveness analysis suggests that germline PTEN testing is cost effective if the probability of a mutation is greater than 10% (cited Ngeow et al. as reference 155).
This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.
  • Updated: May 19, 2016

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