Current Highlight from April 8, 2016
Serum microRNAs Distinguish Drug-Induced and Fatty Liver Disease of Different Grades
NCTR scientists examined a collection of rat and human genomic datasets to identify non-invasive serum microRNAs capable of discerning drug-induced steatosis (DIS) from non-alcoholic fatty liver disease (NAFLD) of different severity. The analyses identified 157 unique microRNAs associated with DIS, 24 with advanced NAFLD, and 9 with mild NAFLD. Steatosis is an accumulation of fat within the liver and can lead to the advanced form of NAFLD which is one of the most common indications for liver transplantation. Development of non-invasive microRNA biomarkers discerning DIS from NAFLD of different grades could aid in early detection and in monitoring disease progression in a clinical setting. A manuscript reporting the study is available online atScientific Reports
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.For additional information, please contact Weida Tong, Ph.D., Director, Division of Bioinformatics and Biostatistics, FDA/NCTR.
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