Lynch Syndrome & Aspirin: What's the Evidence? - September 1, 2015

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Lynch Syndrome

Lynch Syndrome & Aspirin: What's the Evidence? - September 1, 2015

CDC Info

• Genetic Testing for Hereditary Colorectal Cancer
• Screen for Life: National Colorectal Cancer Action Campaign
• Colorectal Cancer Awareness
• Listen to a CDC podcast about Genetic Testing for Lynch syndrome

An aspirin a day keeps the CRC at bay in Lynch syndrome 
Nature Reviews Oncology, September 1, 2015

Obesity, aspirin, and risk of colorectal cancer in carriers of hereditary colorectal cancer: A prospective investigation in the CAPP2 study.
Movahedi M et al. J. Clin. Oncol. 2015 Aug 17.

Aspirin, ibuprofen, and the risk of colorectal cancer in Lynch syndrome.
Ait Ouakrim D et al. J. Natl. Cancer Inst. 2015 Sep (9)

Aspirin in gastrointestinal oncology: new data on an old friend.
Langley RE et al. Curr Opin Oncol 2014 Jul (4) 441-7

Chemoprevention in Lynch syndrome.
Burn J et al. Fam. Cancer 2013 Dec (4) 707-18

Aspirin may help colon cancer patients live longer.
Harv Health Lett 2013 Jan (3) 8

Lynch syndrome: history, causes, diagnosis, treatment and prevention (CAPP2 trial).
Burn J et al. Dig Dis 2012 39-47

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.
Mathers JC et al. Lancet Oncol. 2012 Dec (12) 1242-9

Effects of aspirin on colorectal cancer related to Lynch syndrome.
Beck SL et al. J Adv Pract Oncol 2012 Nov (6) 395-8

No easy answers about whether aspirin lowers cancer risk, National Cancer Institute

Lynch Syndrome: Recent Insights - August 4, 2015

Women with double primary cancers of the colorectum and endometrium: do they have Lynch syndrome?
Song T et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 2015 Aug 19.

Lynch Syndrome: AGA patient guideline summary.
Gastroenterology 2015 Jul 26.

American Gastroenterological Association Institute guideline on the diagnosis and management of Lynch syndrome.
Rubenstein JH et al. Gastroenterology 2015 Jul 27.

Screening for Lynch syndrome among patients with newly diagnosed endometrial cancer: a comprehensive review.
Aguirre E et al. Tumori 2015 Jul 15. (0) 0

Screening for Lynch syndrome and referral to clinical genetics by selective mismatch repair protein immunohistochemistry testing: an audit and cost analysis.
Colling R et al. J. Clin. Pathol. 2015 Jul 22.

DNA mismatch repair status predicts need for future colorectal surgery for metachronous neoplasms in young individuals undergoing colorectal cancer resection.
Aronson M et al. Dis. Colon Rectum 2015 Jul 58(7) 645-52

Female hormonal factors and the risk of endometrial cancer in Lynch syndrome.
Dashti SG et al. JAMA 2015 Jul 7. (1) 61-71

A prospective six sigma quality improvement trial to optimize universal screening for genetic syndrome among patients with young-onset colorectal cancer.
Dineen S et al. J Natl Compr Canc Netw 2015 Jul (7) 865-72

Diagnosis of constitutional mismatch repair-deficiency syndrome based on microsatellite instability and lymphocyte tolerance to methylating agents.
Bodo S et al. Gastroenterology 2015 Jun 24.

Aspirin, ibuprofen, and the risk of colorectal cancer in Lynch syndrome.
Ait OD et al. J. Natl. Cancer Inst. 2015 Sep (9)

Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study.
Harkness EF et al. J. Med. Genet. 2015 Jun 22.

Multivariate analysis as a method for evaluating the pathogenicity of novel genetic MLH1 variants in patients with colorectal cancer and microsatellite instability.
Duraturo F et al. Int. J. Mol. Med. 2015 Aug (2) 511-7

Advances in the study of Lynch syndrome in China.
Lu Jun-Y et al. World J. Gastroenterol. 2015 Jun 14. (22) 6861-6871

Lynch syndrome and cervical cancer.
Antill YC et al. Int. J. Cancer 2015 Jun 15.

Mismatch Repair Deficiency & Immune Therapy: Recent Insights - June 9, 2015

Universal tumor screening for lynch syndrome: Assessment of the perspectives of patients with colorectal cancer regarding benefits and barriers.
Hunter JE et al. Cancer 2015 Jun 2.

A surprising match: Cancer immunotherapy and mismatch repair, Francis Collins, Director's Blog, June 9

PD-1 blockade in tumors with mismatch-repair deficiency
Le DT , et al. NEJM, May 29, 2015

Together, genetic test and drug unleash immune system against tumors, by Matt Herper, Forbes News, May 29

ASCO studies highlight promising biomarkers for predicting response in CRC, lung cancer patients,by Turna Ray, Genomeweb Daily, May 30 [by paid subscription only]

ASCO 2015: Mismatch repair deficiency predicts response to pembrolizumab among patients with colorectal and other cancers, ASCO Post, May 29, 2015

Microsatellite instability: an update.
Yamamoto Hi et al. Arch. Toxicol. 2015 Jun (6) 899-921

Mismatch repair gone awry: management of Lynch syndrome.
Zhang T et al. Crit. Rev. Oncol. Hematol. 2015 Mar (3) 170-9

Lynch Syndrome: Insights into Diagnosis and Screening - May 13, 2015

Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: A cost-effectiveness analysis
Gallego CJ, et al. J Clin Oncology, May 12, 2015

Next-generation sequencing panels cost-effective for diagnosis of hereditary colorectal cancer,Cancer Therapy Advisor, May 12

Scanxiety with Lynch syndrome, by Georgia Hurst, Cure Today, Apr 27

A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients.
Snowsill T et al. BMC Cancer 2015 Apr 25. (1) 313

Stakeholder perspectives on implementing a universal Lynch syndrome screening program: a qualitative study of early barriers and facilitators.
Schneider JL et al. Genet. Med. 2015 Apr 16.

Variation in Lynch syndrome.
Church J et al. Dis. Colon Rectum 2015 May (5) e77

One size may not fit all: The debate of universal tumor testing for Lynch syndrome.
Lu KH et al. Gynecol. Oncol. 2015 Apr (1) 2-3

Decisions about prophylactic gynecologic surgery: a qualitative study of the experience of female Lynch syndrome mutation carriers.
Etchegary H et al. Hered Cancer Clin Pract 2015 (1) 10

Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer.
Kallenberg FG et al. Fam. Cancer 2015 Mar 24.

Risk-reducing surgery in hereditary gynecological cancer: Clinical applications in Lynch syndrome and hereditary breast and ovarian cancer.
Adachi M et al. Mol Clin Oncol 2015 Mar (2) 267-273

Family matters in Lynch syndrome.
Kastrinos F et al. J. Natl. Cancer Inst. 2015 Apr (4)

Lynch Syndrome Awareness - April 6, 2015

Lynch syndrome: Five unanswered questions.
Castellsagué Ester et al. Clin. Genet. 2015 Mar 2.

Sharing hope from cancer experience, by Sheldon Birnie, Winnipeg Free Press, Mar 13

A modified Lynch syndrome screening algorithm in colon cancer: BRAF immunohistochemistry is efficacious and cost beneficial.
Roth Rachel M et al. Am. J. Clin. Pathol. 2015 Mar (3) 336-43

Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers.
Kobayashi Yusuke et al. Int. J. Gynecol. Cancer 2015 Mar (3) 440-6

Improving the uptake of predictive testing and colorectal screening in Lynch syndrome: a regional primary care survey.
Barrow P et al. Clin. Genet. 2015 Feb 4.

Milestones of Lynch syndrome: 1895-2015.
Lynch Henry T et al. Nat. Rev. Cancer 2015 Feb 12.

Lynch syndrome: The basics, by Dennis Ahnen, Fight Colorectal Cancer Blog Post, Jan 15

Economic evaluation of genetic screening for Lynch syndrome in Germany. 
Franziska Severin, et al. Genetics in Medicine, January 8, 2015

Barriers and motivators for referral of patients with suspected Lynch syndrome to cancer genetic services: A qualitative study
Tan YY & Fitzgerald LJ J Pers Med 2014;4(1):20-34

Next-generation strategies for hereditary colorectal cancer risk assessment. 
Yurgelun MB J Clin Oncol. 2015 Jan 5. pii: JCO.2014.58.9895.

Screening for Lynch syndrome: It is time to shift the focus
Kidambi TD & Terdiman JP Dig Dis Sci 2015 Jan

Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndrome.  
Gould-Suarez M, et al. Dig Dis Sci 2014 Dec;59(12)2913-26.

Comparative effectiveness of screening strategies for Lynch syndrome.
Barzi A et al. J. Natl. Cancer Inst. 2015 Apr 107(4)

Lynch Syndrome: Recent Insights - November 6, 2014

Applying public health screening criteria: How does universal newborn screening compare to universal tumor screening for Lynch syndrome in adults with colorectal cancer?
Cragun D, et al. J Genet Couns. 2014 Oct 18

Is it all Lynch syndrome?: An assessment of family history in individuals with mismatch repair–deficient tumors. 
Katherine M. Dempsey et al. Genetics in Medicine, October 23, 2014  

Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome. 
Esplen M, et al. Clin Genet. 2014 Oct 9.

Colonoscopy in patients with Lynch syndrome: no room for error.
Kravochuck SE, Church JM. ANZ J Surg. 2014 Oct 29

Identifying Persons with Lynch Syndrome: Why and How?
Ladabaum U. Dig Dis Sci. 2014 Oct 26.

The impact of risk-reducing gynaecological surgery in premenopausal women at high risk of endometrial and ovarian cancer due to Lynch syndrome.
Moldovan R, Keating S, Clancy T. Fam Cancer. 2014 Oct 24.

Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome.
Esplen MJ, et al. Clin Genet. 2014 Oct 9.

Lynch Syndrome: Awareness and Implementation - September 25, 2014

CDC information: Genetic testing for hereditary colorectal cancer

CDC public health genomics implementation tool kit for health departments- check out Lynch syndrome section

Genetic testing of tumor is recommended for colorectal cancer patients, Science Daily Aug 5

Guidelines on genetic evaluation and management of Lynch syndrome: A consensus statement by the US Multi-Society Task Force on Colorectal Cancer. 
Giardiello FM et al. Dis Colon Rectum. 2014 Aug;57(8):1025-48

NCCN updates guidelines for hereditary colon cancer testing, (March, 2014)

CDC podcast: Genetic testing for Lynch Syndrome in colorectal cancer

Colonoscopy screening compliance and outcomes in patients with Lynch Syndrome. 
Newton K et al.  Colorectal Dis. 2014 Sep 11

Lynch Syndrome - GeneReviews® - NCBI Bookshelf by W Kohlmann et al. (2012)

Lynch syndrome: a pediatric perspective.
SC Huang  et al. J Pediatr Gastroenterol Nutr. 2014

Lynch Syndrome Screening Network- Vision is to reduce the cancer burden associated with Lynch syndrome

Lynch Syndrome International: Mission is to provide support for individuals afflicted with Lynch syndrome, create public awareness of the syndrome, and educate the general public and health care professionals