Malaria: Public Health and Genomic Insights - September 23, 2015

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Malaria

Malaria: Public Health and Genomic Insights - September 23, 2015

CDC and Related Info

• Parasitic disease and malaria strategic priorities: 2015—2020
• Partners turn the tide against malaria
• More than 200 million cases of malaria occur worldwide every year
• AMD Projects: Next-Generation Malaria Methods
• Protective effects of sickle cell trait against malaria-associated mortality and morbidity
• Genes reported in relation to malaria, including genomewide association studies via theHuGE Navigator

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study
Uyoga S et al. Lancet, September, 2015

Glucose-6-phosphate dehydrogenase deficiency and haemoglobin drop after sulphadoxine-pyrimethamine use for intermittent preventive treatment of malaria during pregnancy in Ghana - a cohort study.
Owusu R et al. PLoS ONE 2015 (9) e0136828

Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency.
Kheng S et al. BMC Med 2015 203

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015).
Malar. J. 2015 295

Hemoglobin E and glucose-6-phosphate dehydrogenase deficiency and plasmodium falciparum malaria in the Chittagong Hill Districts of Bangladesh.
Shannon KL et al. Am. J. Trop. Med. Hyg. 2015 Aug 5. (2) 281-6

G6PD deficiency and hemoglobinopathies: molecular epidemiological characteristics and healthy effects on malaria endemic Bioko Island, Equatorial Guinea.
Lin M et al. PLoS ONE 2015 (4) e0123991

G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study.
Peixoto HM et al. Malar. J. 2015 126

G6PD gene variants and its association with malaria in a Sri Lankan population.
Dewasurendra RL et al. Malar. J. 2015 93

Evaluation of the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) in a malaria endemic area in Ghana, Africa.
Adu-Gyasi D et al. PLoS ONE 2015 (4) e0125796

World Malaria Day: April 25, 2015 - April 25, 2015

CDC information: Partners turn the tide against malaria

World Malaria Day

Antimalarial drug resistance in Africa: key lessons for the future.
Takala-Harrison S et al. Ann. N. Y. Acad. Sci. 2015 Apr (1) 62-7

The case for a rational genome-based vaccine against malaria.
Proietti Ca et al. Front Microbiol 2014 741

Paths to a malaria vaccine illuminated by parasite genomics.
Conway DJ et al. Trends Genet. 2015 Feb (2) 97-107

The utility of genomic data for Plasmodium vivax population surveillance.
Daniels RF et al. Pathog Glob Health 2015 Apr 18.

The genetic control of immunity to Plasmodium infection.
Grant AV et al. BMC Immunol. 2015 14

Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphism.
Pinheiro MM et al. PLoS ONE 2015 (4) e0121303

USP38, FREM3, SDC1, DDC and LOC727982 gene polymorphisms and differential susceptibility to severe malaria in Tanzania.
Manjurano A et al. J. Infect. Dis. 2015 Mar 24.

Towards genome-wide experimental genetics in the in vivo malaria model parasite Plasmodium berghei.
Matz JM et al. Pathog Glob Health 2015 Mar (2) 46-60

Malaria: Genomic Insight Into Drug Resistance - January 23, 2015

Genetics of malaria drug resistance revealed, by Rebecca Morelle, BBC News, Jan 19
 
Genetic architecture of artemisinin-resistant Plasmodium falciparum. 
Olivo Miotto, et al. Nature Genetics, January 19, 2015

Understanding antimalarial drug resistance
Vence T. The Scientist, Jan 21, 2015.

Plasmodium falciparum dihydropteroate synthetase-A581G mutation reduces effectiveness of sulfadoxine-pyrimethamine preventive therapy in Malawian pregnant women
Gutman J, et al. J Infect Dis, Jan 6, 2015.

Malaria Resistance: Role of Genomics - December 30, 2014

The genetics of resistant malaria. 
Gretchen Vogel et al. Science, December 11, 2014

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.
Rout S, et al.  J Microbiol Methods. 2014 Dec 5

Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers.
Almelli T, et al. PLoS One. 2014 Dec 5;9(12):e114401

Drug resistance genomics of the antimalarial drug artemisinin.
Winzeler EA, Manary MJ. Genome Biol. 2014 Nov 25

Interferon-γ (IFNG) microsatellite repeat and single nucleotide polymorphism haplotypes of IFN-α receptor (IFNAR1) associated with enhanced malaria susceptibility in Indian populations.
Kanchan K, et al. Infect Genet Evol. 2014 Nov 7;

Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae: known and novel candidate genes.
Ingham VA, et al. BMC Genomics. 2014 Nov 25;

Malaria: Recent Genomic Insights - September 11, 2014

CDC information: More than 200 million cases of malaria occur worldwide every year

CDC information: Replacing outdated malaria drug resistance screening methods with next-generation molecular tools and techniques

CDC information: Protective effects of sickle cell trait against malaria-associated mortality and morbidity

Malaria diagnostics and surveillance in the post-genomic era: A review 
Lucchi N, Oberstaller L, Kissinger J, et al. Public Health Genomics, 2013;16:37-43

Did you know? 230 genes have been reported in relation to risk or outcomes of malaria, including 8 genomewide association studies. Find out more using the HuGE Navigator

A genomic revolution in malaria research, by Olivo Miotto, Wellcome Trust Sanger Institute blog post, Jan 10, 2014

Resistance gene identified in malaria parasite, by Ewen Callaway, Nature News, Dec 18, 2013

Genomics reveals mechanism for malaria drug resistance, Drug Discovery & Development, Jul 25, 2014

Single-cell genomics for dissection of complex malaria infections. 
Shalini Nair et al. Genome Research, May 2014

Recent CDC paper: Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda
Mbogo GW, et al.  Am J Trop Med Hyg. 2014 May 5.  

Preferential feeding success of laboratory reared Anopheles stephensi mosquitoes according to ABO blood group status. 
Anjomruz M  et al. Acta Trop. 2014 Aug 20.