Putative Lineage of Novel African Usutu Virus, Central Europe - Volume 21, Number 9—September 2015 - Emerging Infectious Disease journal - CDC
Volume 21, Number 9—September 2015
Putative Lineage of Novel African Usutu Virus, Central Europe
Originally isolated from a Culex neavei mosquito in South Africa in 1959 (1,2), Usutu virus (USUV) was subsequently detected in different mosquito and bird species throughout Sub-Saharan countries (3). USUV has recently been introduced to Europe, where it caused widespread deaths among resident bird populations, established a local transmission cycle, and became a resident pathogen (4–6). USUV is maintained in an enzootic cycle involving mosquitoes as vectors and birds as the main amplifying hosts; humans are considered incidental or dead-end hosts. We have demonstrated that bats could also be infected with USUV and might act as amplifying hosts (7), and there is increasing evidence that USUV is pathogenic for humans, thus becoming a potential public health problem (8,9). On the basis of genetic differences, in comparison with the USUV strains from Africa, the USUV strains from Europe, except those from Spain, form a distinct clade within USUV phylogeny (7). The detection and isolation of USUV from different bird species and mammalophilic mosquitoes during the 2011 epizootic in Germany raised questions regarding the USUV host range. Thus, as a part of the German Arbovirus Surveillance Program (10), we continued the monitoring of the mosquitoes, birds, and bats for the presence of USUV.
Dr. Cadar is a postdoctoral researcher at the Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. His research interests include the arbovirus ecology, evolutionary genetics of viral emergence, and arbovirus discovery.
We thank Alexandra Bialonski, Martin Rudolf, Claudia Poggensee, Mathis Petersen, Birgit Hüsing, Corinna Thomè, and Sabine Köhler for excellent technical assistance.
- Williams MC, Simpson DI, Haddow AJ, Knight EM. The isolation of West Nile virus from man and of Usutu virus from the bird-biting mosquitoMansonia aurites (Theobald) in the Entebbe area of Uganda. Ann Trop Med Parasitol. 1964;58:367–74 .PubMed
- McIntosh BM. Usutu (SA Ar 1776), nouvel arbovirus du groupe B. International Catalogue of Arboviruses. 1985;3:1059–60.
- Nikolay B, Diallo M, Boye CS, Sall AA. Usutu virus in Africa. Vector Borne Zoonotic Dis. 2011;11:1417–23 . DOIPubMed
- Weissenböck H, Kolodziejek J, Url A, Lussy H, Rebel-Bauder B, Nowotny N. Emergence of Usutu virus, an African mosquitoborne flavivirus of the Japanese encephalitis virus group, central Europe. Emerg Infect Dis. 2002;8:652–6. DOIPubMed
- Becker N, Jöst H, Ziegler U, Eiden M, Höper D, Emmerich P, Epizootic emergence of Usutu virus in wild and captive birds in Germany. PLoS ONE.2012;7:e32604. http://dx.doi.org/10.1371/ journal.pone.0032604.
- Savini G, Monaco F, Terregino C, Di Gennaro A, Bano L, Pinoni C, Usutu virus in Italy: an emergence or a silent infection? Vet Microbiol.2011;151:264–74. DOIPubMed
- Cadar D, Becker N, Campos Rde M, Börstler J, Jöst H, Schmidt-Chanasit J. Usutu virus in bats, Germany, 2013. Emerg Infect Dis. 2014;20:1771–3.DOIPubMed
- Pecorari M, Longo G, Gennari W, Grottola A, Sabbatini A, Tagliazucchi S, First human case of Usutu virus neuroinvasive infection, Italy, August–September 2009. Euro Surveill. 2009;14:19446 .PubMed
- Vilibic-Cavlek T, Kaic B, Barbic L, Pem-Novosel I, Slavic-Vrzic V, Lesnikar V, First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak. Infection. 2014;42:689–95. DOIPubMed
- Becker N, Krüger A, Kuhn C, Plenge-Bönig A, Thomas SM, Schmidt-Chanasit J, Mosquitoes as vectors for exotic pathogens in Germany.Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014;57:531–40. DOIPubMed
- Jöst H, Bialonski A, Maus D, Sambri V, Eiden M, Groschup MH, Isolation of Usutu virus in Germany. Am J Trop Med Hyg. 2011;85:551–3.DOIPubMed
- Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59:307–21 .DOIPubMed
- Ronquist F, Huelsenbeck JP. MRBAYES 3: Bayesian phylogenetic inference under mixed models. Bioinformatics. 2003;19:1572–4. DOIPubMed
- Liu WJ, Wang XJ, Mokhonov VV, Shi PY, Randall R, Khromykh AA. Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. J Virol. 2005;79:1934–42 .DOIPubMed
Suggested citation for this article: Cadar D, Bosch S, Jöst H, Börstler J, Garigliany MM, Becker N, et al. Putative lineage of novel African Usutu virus, central Europe. Emerg Infect Dis. 2015 Sep [date cited]. http://dx.doi.org/10.3201/eid2109.142026
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