Diverse brain tumor subtypes have an unanticipated common origin

Oct. 20, 2014

—A Neves

Predicted evolutionary trajectory for non-glioma-CpG island methylator phenotype glioblastoma (non-GCIMP GBM). Broad copy number alterations in chromosome 7 and chromosome 10 appear to be the earliest events, which boosts proliferation of glioma precursors. Next, loss of the tumor suppressors CDKN2A and TP53 occurs. Finally, the proneural GBM precursor acquires subtype-enriched mutations, such as NF1 loss for the mesenchymal (mes) subtype.
Image provided by Dr. Ozawa