Impact of maternal immunization on influenza hospitalizations in infants

Impact of maternal immunization on influenza hospitalizations in infants

Presented, in part, at the 2005 Pediatric Academic Societies Meeting in Washington, DC, May 16, 2005.

* Katherine A. Poehling, MD, MPH
Affiliations
o Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC
o Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC
* , Peter G. Szilagyi, MD, MPH
Affiliations
o Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY
* , Mary A. Staat, MD, MPH
Affiliations
o Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
* , Beverly M. Snively, PhD
Affiliations
o Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC
* , Daniel C. Payne, PhD, MSPH
Affiliations
o National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA
* , Carolyn B. Bridges, MD
Affiliations
o National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA
* , Susan Y. Chu, PhD, MSPH
Affiliations
o Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
* , Laney S. Light, MS
Affiliations
o Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC
* , Mila M. Prill, MSPH
Affiliations
o National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA
* , Lyn Finelli, DrPH
Affiliations
o National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA
* , Marie R. Griffin, MD, MPH
Affiliations
o Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN
o Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, TN
* , Kathryn M. Edwards, MD
Affiliations
o Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
* , New Vaccine Surveillance Network

Received 16 December 2010; received in revised form 4 February 2011; accepted 14 February 2011. published online 24 February 2011.

* Abstract

We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32–0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30–0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.

open here please:
Impact of maternal immunization on influenza hospitalizations in infants: "- Enviado mediante la barra Google"




Actualidad Ultimas noticias - JANOes - La vacuna contra la gripe en las mujeres embarazadas tambien protege a los recien nacidos - JANO.es - ELSEVIER: "GINECOLOGÍA
La vacuna contra la gripe en las mujeres embarazadas también protege a los recién nacidos

JANO.es · 04 Julio 2011 09:13

Una investigación clínica revela que los bebés cuyas madres habían recibido la vacuna contra la gripe en el embarazo tenían entre 45% y 48% menos probabilidades de ser hospitalizados por influenza.

Vacunar a las mujeres embarazadas contra la gripe también protege a sus recién nacidos, de acuerdo con la información de American Journal of Obstetrics & Gynecology. La vacuna contra la gripe se recomienda a todas las personas a partir de los seis meses de edad, pero no está aprobada para niños menores de seis meses, que tienen las tasas más elevadas de hospitalización por gripe de todos los niños.

En este estudio, investigadores de Estados Unidos analizaron datos de unos 1.500 bebés que fueron hospitalizados por fiebre o problemas respiratorios en sus primeros seis meses de vida, y que se sometieron a pruebas de laboratorio para la infección con influenza.

Los resultados mostraron que los bebés cuyas madres habían recibido la vacuna contra la gripe en el embarazo tenían entre 45% y 48% menos probabilidades de ser hospitalizados por influenza confirmada en el laboratorio.

'Se recomienda que todas las mujeres embarazadas reciban la vacuna contra la influenza durante el embarazo, ya que se sabe que las mujeres embarazadas tienen una mayor morbilidad y mortalidad durante el embarazo y el período inmediatamente posterior al parto si contraen gripe', señaló la autora principal, la Dra. Katherin A. Poehling, de la Wake Forest School of Medicine (Estados Unidos).

'También sabemos que las madres traspasan anticuerpos a través de la placenta para ayudar al bebé', añadió. 'Este estudio mostró que recibir la vacuna contra la influenza en el embarazo no sólo protege a la madre, sino que también protege al bebé en los primeros meses de vida.'


American Journal of Obstetrics & Gynecology 2011;204:S141-S148 ► Impact of maternal immunization on influenza hospitalizations in infants: "- Enviado mediante la barra Google"


Wake Forest School of Medicine ► About the School of Medicine - Wake Forest Baptist Medical Center: "- Enviado mediante la barra Google"


Actualidad Ultimas noticias - JANOes - La vacuna contra la gripe en las mujeres embarazadas tambien protege a los recien nacidos - JANO.es - ELSEVIER: "GINECOLOGÍA
La vacuna contra la gripe en las mujeres embarazadas también protege a los recién nacidos - Enviado mediante la barra Google"