Genetic testing for lynch syndrome in individuals ... [PLoS Curr. 2011] - PubMed result

full-text one ►Genetic testing for lynch syndrome in individuals ... [PLoS Curr. 2011] - PubMed result: "PLoS Curr. 2011 Jul 6;3:RRN1246.
Genetic testing for lynch syndrome in individuals newly diagnosed with colorectal cancer to reduce morbidity and mortality from colorectal cancer in their relatives.
Coates R, Williams M, Melillo S, Gudgeon J.
Source
Associate Director for Science, Public Health Surveillance Program Office, Centers for Disease Control and Prevention; Director, Intermountain Healthcare Clinical Genetics Institute; Office of Public Health Genomics, Centers for Disease Control and Prevention and Health services research, focus in clinical genetics.

Abstract

Individuals with Lynch syndrome, sometimes referred to as hereditary non-polyposis colorectal cancer (HNPCC), have an increased risk of developing colorectal cancer (CRC) as well as other cancers. The increased risk is due to inherited mutations in mismatch repair (MMR) genes, which reduce the ability of cells to repair DNA damage. Screening for Lynch syndrome in individuals newly diagnosed with colorectal cancer has been proposed as part of a strategy that combines tests and interventions to reduce the risk of colorectal cancer in the relatives of the colorectal cancer patients with Lynch Syndrome.

PMID:
21743847
[PubMed]
PMCID: PMC3130897

Free PMC Article ►
Genetic Testing for Lynch Syndrome in Individuals Newly Diagnosed with Colorectal Cancer to Reduce Morbidity and Mortality from Colorectal Cancer in Their Relatives: "- Enviado mediante la barra Google"
- Enviado mediante la barra Google"