Azole Resistance in Aspergillus fumigatus Isolates... [Antimicrob Agents Chemother. 2011] - PubMed result

Azole Resistance in Aspergillus fumigatus Isolates... [Antimicrob Agents Chemother. 2011] - PubMed result: "Antimicrob Agents Chemother. 2011 Jun 20. [Epub ahead of print]
Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene.
Lockhart SR, Frade JP, Etienne KA, Pfaller MA, Diekema DJ, Balajee SA.
Source

Mycotic Diseases Branch, Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.

Abstract

We surveyed 497 isolates of Aspergillus fumigatus collected 2008-2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazole, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside of Europe.

PMID:
21690285
[PubMed - as supplied by publisher]

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