Stroke: Folates, Genetics and Public Health - March 16, 2015

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Stroke: Folates, Genetics and Public Health - March 16, 2015

Folate supplements for stroke prevention - targeted trial trumps the rest
Stampfer M et al. JAMA March 12, 2015

Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China - the CSPPT randomized clinical trial
Y H et al. JAMA, March 12, 2015

Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction.
Cho Y et al. PLoS ONE 2015 (2) e0115295

Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the vitamin intervention for stroke prevention (VISP) trial.
Keene KL et al. Front Public Health 2014 112

Quantitative assessment of association between rs1801133 polymorphism and susceptibility to stroke.
Zhang W et al. Cell Biochem. Biophys. 2015 Jan (1) 85-98

Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives: an epistasis analysis.
Wei LK et al. J Hum Hypertens 2015 Feb (2) 99-104

Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population.
Zhou BS et al. Int J Mol Sci 2014 (5) 8931-40

Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
Williams SR et al. PLoS Genet. 2014 Mar (3) e1004214

Strokes in young adults: epidemiology and prevention.
Smajlovic D Vasc Health Risk Manag 2015 157-164

Cytochrome 4A11 genetic polymorphisms increase susceptibility to ischemic stroke and associate with atherothrombotic events after stroke in Chinese.
Zhang B et al. Genet Test Mol Biomarkers 2015 Mar 3.

Next generation sequencing for systematic assessment of genetics of small-vessel disease and lacunar stroke.
Bersano A et al. J Stroke Cerebrovasc Dis 2015 Feb 26.

Stroke: Genetics & Public Health - October 22, 2014

CDC Information: October 29 is World Stroke Day- Stroke is the fourth leading cause of death in the United States and is a major cause of adult disability. About 800,000 people in the United States have a stroke each year. 

CDC information: Family history and other characteristics increase risk for stroke

Am I at risk for a stroke? Family history is a risk factor for stroke, from the National Stroke Association

Did you know? More than 752 genes have been reported in relation to risk and outcomes of stroke/ cerebrovascular accident, including 44 genomewide association studies?

Did you know? About 10% of children with sickle cell disease will have a symptomatic stroke? Learn about complications of sickle cell disease and how to prevent them

Researchers discover underlying genetics, marker for stroke, cardiovascular disease, NIH News (March 2014)

Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes.
Meschia JF et al. Stroke, October 2013

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Matthew Traylor mail et al. PLOS Genetics (2014)