Two variants of LPA gene associated with increased risk of coronary heart disease

Two variants of LPA gene associated with increased risk of coronary heart disease
9. June 2010 04:58


Celera Corporation (NASDAQ:CRA) and its collaborators at the University of California at San Francisco today announced the publication of a paper confirming the association of an increased risk of coronary heart disease (CHD) and two variants of the LPA gene. The two LPA single nucleotide polymorphisms (SNPs) are Ile4399Met, a polymorphism in the protease-like domain of LPA, and rs10455872, a SNP located in a non-coding region of the LPA gene. The paper is available on the journal's website at http://atherosclerosis-journal.com/inpress.

“Moreover, we believe this publication will motivate functional biology follow-up studies to gain insight into the mechanistic involvement of the LPA gene in disease. These studies also emphasize the field's growing appreciation of the role of less common alleles in risk for disease.”

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Two variants of LPA gene associated with increased risk of coronary heart disease