martes, 1 de enero de 2013

National Guideline Clearinghouse | Chronic fatigue syndrome/myalgic encephalomyelitis. A primer for clinical practitioners.

full-text ►
National Guideline Clearinghouse | Chronic fatigue syndrome/myalgic encephalomyelitis. A primer for clinical practitioners.

National Guideline Clearinghouse (NGC)

December 31, 2012


Guideline Title
Chronic fatigue syndrome/myalgic encephalomyelitis. A primer for clinical practitioners.
 
Bibliographic Source(s)
International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME). Chronic fatigue syndrome/myalgic encephalomyelitis. A primer for clinical practitioners. Chicago (IL): International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFS/ME); 2012. 41 p. [121 references]
 
Guideline Status
This is the current release of the guideline.

National Guideline Clearinghouse | Clinical policy: critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy.

full-text ►
National Guideline Clearinghouse | Clinical policy: critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy.

National Guideline Clearinghouse (NGC)

December 31, 2012


Guideline Title
Clinical policy: critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy.
 
Bibliographic Source(s)
Hahn SA, Lavonas EJ, Mace SE, Napoli AM, Fesmire FM, American College of Emergency Physicians. Clinical policy: critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy. Ann Emerg Med 2012 Sep;60(3):381-90.e28. [55 references] PubMed External Web Site Policy
 
Guideline Status
This is the current release of the guideline.
This guideline updates a previous version: Clinical policy: critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy. Ann Emerg Med 2003 Jan;41(1):123-33.


Ann Emerg Med. 2012 Sep;60(3):381-90.e28. doi: 10.1016/j.annemergmed.2012.04.021.

Clinical policy: Critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy.

Abstract

This clinical policy from the American College of Emergency Physicians is the revision of the 2003 Clinical Policy: Critical Issues in the Initial Evaluation and Management of Patients Presenting to the Emergency Department in Early Pregnancy.(1) A writing subcommittee reviewed the literature to derive evidence-based recommendations to help clinicians answer the following critical questions: (1) Should the emergency physician obtain a pelvic ultrasound in a clinically stable pregnant patient who presents to the emergency department (ED) with abdominal pain and/or vaginal bleeding and a beta human chorionic gonadotropin (β-hCG) level below a discriminatory threshold? (2) In patients who have an indeterminate transvaginal ultrasound, what is the diagnostic utility of β-hCG for predicting possible ectopic pregnancy? (3) In patients receiving methotrexate for confirmed or suspected ectopic pregnancy, what are the implications for ED management? Evidence was graded and recommendations were developed based on the strength of the available data in the medical literature. A literature search was also performed for a critical question from the 2003 clinical policy.(1) Is the administration of anti-D immunoglobulin indicated among Rh-negative women during the first trimester of pregnancy with threatened abortion, complete abortion, ectopic pregnancy, or minor abdominal trauma? Because no new, high-quality articles were found, the management recommendations from the previous policy are discussed in the introduction.
PMID:
22921048
[PubMed - indexed for MEDLINE] 
Clinical policy: Critical issues in the initia... [Ann Emerg Med. 2012] - PubMed - NCBI

National Guideline Clearinghouse | Consensus treatment recommendations for late-onset Pompe disease.

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National Guideline Clearinghouse | Consensus treatment recommendations for late-onset Pompe disease.

National Guideline Clearinghouse (NGC)

December 31, 2012


Guideline Title


Consensus treatment recommendations for late-onset Pompe disease.

Bibliographic Source(s)

Cupler EJ, Berger KI, Leshner RT, Wolfe GI, Han JJ, Barohn RJ, Kissel JT, AANEM Consensus Committee on Late-onset Pompe Disease. Consensus treatment recommendations for late-onset Pompe disease. Muscle Nerve 2012 Mar;45(3):319-33. [108 references] PubMed External Web Site Policy
Guideline Status

This is the current release of the guideline.


Muscle Nerve. 2012 Mar;45(3):319-33. doi: 10.1002/mus.22329. Epub 2011 Dec 15.

Consensus treatment recommendations for late-onset Pompe disease.

Source

Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA.

Abstract

INTRODUCTION:

Pompe disease is a rare, autosomal recessive disorder caused by deficiency of the glycogen-degrading lysosomal enzyme acid alpha-glucosidase. Late-onset Pompe disease is a multisystem condition, with a heterogeneous clinical presentation that mimics other neuromuscular disorders.

METHODS:

Objective is to propose consensus-based treatment and management recommendations for late-onset Pompe disease.

METHODS:

A systematic review of the literature by a panel of specialists with expertise in Pompe disease was undertaken.

CONCLUSIONS:

A multidisciplinary team should be involved to properly treat the pulmonary, neuromuscular, orthopedic, and gastrointestinal elements of late-onset Pompe disease. Presymptomatic patients with subtle objective signs of Pompe disease (and patients symptomatic at diagnosis) should begin treatment with enzyme replacement therapy (ERT) immediately; presymptomatic patients without symptoms or signs should be observed without use of ERT. After 1 year of ERT, patients' condition should be reevaluated to determine whether ERT should be continued.
Copyright © 2011 Wiley Periodicals, Inc.
PMID:
22173792
[PubMed - indexed for MEDLINE] 
Consensus treatment recommendations for late-on... [Muscle Nerve. 2012] - PubMed - NCBI

Research Activities, January 2013: Women's Health: Computerized clinical decision support may promote contraceptive counseling for women prescribed teratogenic medications

Research Activities, January 2013: Women's Health: Computerized clinical decision support may promote contraceptive counseling for women prescribed teratogenic medications

U.S. Department of Health and Human Serviceswww.hhs.gov/
Agency for Healthcare Research Quality

Computerized clinical decision support may promote contraceptive counseling for women prescribed teratogenic medications

Each year, 12 million women of reproductive age receive prescriptions for drugs that can potentially cause birth defects (teratogenic). Alerting women to these risks and providing them with contraceptive counseling is very important. However, less than 50 percent of women actually receive such counseling. A new study concludes that electronic medical records with clinical decision support (CDS) systems can improve counseling and prescribing practices, including the frequency of discussing the risks of medication use during pregnancy.
In the study, 41 primary care physicians (PCPs) received a CDS system. One group was randomized to receive a simple version that delivered a cautionary alert when ordering potentially teratogenic medications. The second group of PCPs received a CDS system that used a tailored alert text and a structured order set for safe prescribing. All PCPs, regardless of which CDS they received, were only alerted once per encounter with a patient. The researchers abstracted data from 35,110 encounters of 9,972 female patients of child-bearing age.
Before CDS was implemented, 24.2 percent of patient visits had documented contraceptive counseling when a teratogenic drug was prescribed. Following CDS implementation, this increased to 26.5 percent in both CDS groups. Those who received the multifaceted CDS reported an increase in the number of times per month they discussed medication risks during pregnancy with women to whom they prescribed teratogenic drugs. They also improved several prescribing and counseling practices. However, PCPs reported more satisfaction with the simple CDS system. Thus, the researchers conclude that, although CDS systems have the potential to boost provision of family planning services when fertile women are prescribed potentially teratogenic medications, further refinement of these systems is needed. Their study was supported in part by the Agency for Healthcare Research and Quality (HS17093).
See "Clinical decision support to promote safe prescribing to women of reproductive age: A cluster-randomized trial," by Eleanor Bimla Schwarz, MD, MS, Sara M. Parisi, MS, MPH, Steven M. Handler, MD, PhD, and others in the Journal of General Internal Medicine 27(7), pp. 831-838, 2012.
— KB

Research Activities, January 2013: Elderly Health/Long-Term Care: Elderly colon cancer patients receiving chemotherapy after surgery are at risk for various toxicities

Research Activities, January 2013: Elderly Health/Long-Term Care: Elderly colon cancer patients receiving chemotherapy after surgery are at risk for various toxicities

www.hhs.gov/
Agency for Healthcare Research Quality
 

Elderly colon cancer patients receiving chemotherapy after surgery are at risk for various toxicities

Patients who receive surgery for stage III colon cancer can benefit from 5-flurouracil (5-FU)-based chemotherapy. However, 5-FU-based chemotherapy is associated with increased risk of developing gastrointestinal (GI), blood, and cardiac toxicities in elderly patients with colon cancer. These patients need to be closely monitored so that the benefits of chemotherapy can outweigh the risks, suggest the study authors. They identified 12,099 patients with stage III colon cancer from a Medicare database. Of these, 4,359 did not receive any chemotherapy following surgery, with the remaining 7,740 (63.9 percent) getting 5-FU-based chemotherapy within 3 months after tumor resection. Researchers calculated the 3-month cumulative incidence rate for GI and blood toxicities and risk for heart disease.
Patients receiving chemotherapy were more likely to be younger, married, and have fewer coexisting conditions than the untreated group. This difference was most pronounced for age, with 88.2 percent of patients aged 65 to 69 initiating chemotherapy compared to just 18.1 percent of patients aged 85 and older. During 3 months after surgery, the cumulative incidence rate of toxicities was 9.1 percent in the chemotherapy group and 4.3 percent in the non-chemotherapy group. Common toxicities included volume depletion disorder, agranulocytosis (potentially lethal reduction in the number of white blood cells), diarrhea, nausea, and vomiting. Women were 35 percent more likely to experience toxicities than men and blacks were 35 percent less likely to develop toxicities than whites. Chemotherapy was only slightly associated with the risk for developing heart disease. The study was supported by the Agency for Healthcare Research and Quality (HS16743).
See "Adjuvant chemotherapy and risk of gastrointestinal, hematologic, and cardiac toxicities in elderly patients with stage III colon cancer," by Chung-Yuan Hu, PhD, Wenyaw Chan, PhD, George P. Declos, MD, PhD, and Xianglin L. Du, MD, PhD, in the June 2012 American Journal of Clinical Oncology 35(3), pp. 228-236.
— KB

Research Activities, January 2013: Elderly Health/Long-Term Care: Partial kidney removal offers survival advantage for elderly patients with small tumors

Research Activities, January 2013: Elderly Health/Long-Term Care: Partial kidney removal offers survival advantage for elderly patients with small tumors

www.hhs.gov/
Agency for Healthcare Research Quality

Partial kidney removal offers survival advantage for elderly patients with small tumors

The number of patients diagnosed with small kidney tumors has increased considerably over the last 2 decades. As a result, partial removal of the affected kidney has replaced complete removal as the standard treatment in order to preserve kidney function. A new study shows that patients treated with partial rather than total removal of the kidney had a significantly lower risk of dying of kidney cancer.

The researchers retrospectively studied the outcomes of 7,138 Medicare patients with early-stage kidney cancer. Thirty-seven (1.9 percent) patients who underwent partial kidney removal died compared to 222 (4.3 percent) of those whose complete kidney was removed. Based on a predicted survival difference of 15.5 percentage points at 8-year follow-up, the researchers estimated that one life would be saved for every seven patients treated with partial rather than total kidney removal.

Although these findings contradict the results of an earlier clinical trial that found a survival benefit for those treated with total kidney removal, the researchers believe that this is because partial kidney removal was much less widely used in the period covered by the clinical trial. At that time, physicians were much less skilled in its intricacies, and the patient population it was applied to differed considerably from those receiving partial kidney removal in the period covered by the newer study. This study was supported in part by the Agency for Healthcare Research and Quality (HS18346).

See "Long-term survival following partial vs. radical nephrectomy among older patients with early-stage kidney cancer" by Hung-Jui Tan, MD, Edward C. Norton, PhD, Zaojun Ye, MS, and others in the April 18, 2012, Journal of the American Medical Association 307(15), pp. 1629-1635.
— MWS

Screening for Hepatitis C Virus Infection in Adults - Research Review - Final | AHRQ Effective Health Care Program

Screening for Hepatitis C Virus Infection in Adults - Research Review - Final | AHRQ Effective Health Care Program

Department of Health and Human Serviceswww.hhs.gov

Review examines Hepatitis C screening effects in adults

A new research review from the Agency for Healthcare Research and Quality's Effective Health Care Program has found that although screening strategies for Hepatitis C Virus (HCV) can accurately identify adults with the disease, more research is needed to understand the effects of targeted screening strategies in adults. The review also noted that evidence remains limited on the effects of knowing one's HCV status on clinical health outcomes in patients diagnosed with HCV.

This review also discusses the effects that screening has on pregnant women and their ability to pass the infection onto their offspring. Studies found no clear association between type of birth delivery and risk of transmission in mothers and children, and consistently found no association between breastfeeding and transmission risk.

These findings are available in the research review Screening for Hepatitis C Virus Infection in Adults that can be found at http://www.effectivehealthcare.ahrq.gov.