Blocking ZFP384 protein extends brain repair window after stroke

https://www.news-medical.net/news/20260713/Blocking-ZFP384-protein-extends-brain-repair-window-after-stroke.aspx Blocking the activity of ZFP384 can prolong the brain’s endogenous repair functions after stroke, report researchers in a collaborative study. They developed an antisense oligonucleotide-based therapy that sustained the reparative activity of microglia by promoting remyelination and neural plasticity, thereby improving functional recovery in mice. Surprisingly, these results were observed even when the treatment began weeks after injury. The findings reveal a promising strategy to extend the brain’s recovery window after stroke, improving long-term outcomes.