Reviving a forgotten cancer therapy By stabilizing G-quadruplex DNA, a revived anticancer drug offers a new way to shut down a key oncogene. Written byBree Foster, PhD

https://www.drugdiscoverynews.com/reviving-a-forgotten-cancer-therapy-17272?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8CY1VzKLmaRsoFTXDnaY9N4PIMIhKlDLVvvJLQdcd2sqN_9fDOJs7Y_M5eVVEsPiQOsWdDUPJZNYgYaGxQP6XFNkc8XA&_hsmi=427377385&utm_content=427377385&utm_source=hs_email DNA is usually taught as a tidy double helix: two strands neatly twisted around each other, carrying genetic instructions that cells read and copy. But in reality, DNA is far messier than textbook diagrams suggest. Under certain conditions, stretches of DNA rich in the base guanine can fold in on themselves, forming compact, knot-like shapes known as G-quadruplexes, or G4 structures. Instead of the familiar two-stranded helix, four strands of DNA stack together, creating a three-dimensional structure that can physically block the cell’s transcription machinery.