The effects of anti-osteoporotic medication on fracture healing and outcomes: a systematic review and meta-analysis Nikhil Agarwal, MBChBa ∙ Katrina R Bell, MBChBa ∙ Lauren E Ross, MBChBa ∙ Nick D Clement, PhDa ∙ Prof Stuart H Ralston, MDb ∙ Prof Andrew D Duckworth, PhD

The effects of anti-osteoporotic medication on fracture healing and outcomes: a systematic review and meta-analysis Nikhil Agarwal, MBChBa ∙ Katrina R Bell, MBChBa ∙ Lauren E Ross, MBChBa ∙ Nick D Clement, PhDa ∙ Prof Stuart H Ralston, MDb ∙ Prof Andrew D Duckworth, PhD https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(26)00011-5/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhl&utm_campaign=update-lanhl&utm_medium=email&_hsenc=p2ANqtz--QT3D7JjMNJNvQnfeKvPcFRQYj8hJhWWq9C6gEi2px483V12cDEJ1HeUaayjE4GfdU28vl_Wv_LCLOI_Yscr-biNWiNw&_hsmi=425952808&utm_content=425727608&utm_source=hs_email Bisphosphonates and teriparatide are used in the management of osteoporosis and reduction of fracture risk. However, their effects on fracture healing have been subject to debate, with concerns that the antiresorptive action of these drugs might impair bone remodelling and delay union. This systematic review and meta-analysis aimed to assess the effects of anti-osteoporotic medication on fracture union, clinical outcomes, complications, and patient-reported outcome measures for acute fractures in adults.