Synthetic Human Chromosomes Explained

https://www.news-medical.net/health/Synthetic-Human-Chromosomes-Explained.aspx From synthetic chromosomes and recoded genomes to next-generation gene therapies and engineered cells, discover how genome-scale engineering is redefining the possibilities of biology while reshaping the future of medicine and biotechnology. Synthetic genomics is a specialized branch of synthetic biology characterized by the de novo design, chemical synthesis, assembly, and functional activation of complete genomes or chromosomes to create living viruses or cells. In addition to synthetic microbial genomes, modern genome engineering increasingly focuses on chromosome-scale manipulation, including synthetic yeast chromosomes, human artificial chromosomes (HACs), genome recoding, chromosome fusion, and designer genomes with altered biological properties.1,2,4 Recent advances in genome engineering technologies have enabled the rational design or modification of chromosomal architecture to elicit specific desirable phenotypes, such as viral resistance or customized metabolic pathways.