How do living drugs fit into drug discovery? ++ ++

How do living drugs fit into drug discovery? Living drugs are blurring the line between therapy and biology, challenging decades of assumptions about how medicines are made and controlled. https://www.drugdiscoverynews.com/how-do-living-drugs-fit-into-drug-discovery-17157 For decades, drug discovery has been built around a familiar idea: Design a molecule, manufacture it, and administer it. But that model is now being challenged by a class of therapies that don’t fit neatly within it. So-called “living drugs” — engineered immune cells — do not behave like conventional pharmaceuticals. Once infused, they can expand, migrate, respond to biological signals, and persist long after administration. In effect, they function less like static interventions and more like dynamic biological systems. A 30-minute TB test could finally shift diagnosis out of the lab and into the clinic A multicountry study shows that a point-of-care TB test performs comparably to established molecular diagnostics while offering a simpler workflow and faster turnaround. https://www.drugdiscoverynews.com/a-30-minute-tb-test-could-finally-shift-diagnosis-out-of-the-lab-and-into-the-clinic-17155 Tuberculosis (TB) has been treatable for more than 75 years, yet it remains the world’s deadliest infectious disease, killing more people each year than any other single pathogen. The paradox has long frustrated global health experts: Effective drugs exist, but the disease continues to spread and claim lives, particularly in low- and middle-income countries. The future of tuberculosis diagnosis: using breath to fight disease spread Researchers are developing new, portable breath analysis tools to diagnose tuberculosis and other diseases, making screenings more accessible in remote areas and beyond. https://www.drugdiscoverynews.com/sniffing-out-tuberculosis-in-human-breath-16343?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_g_eAOXpOC9AYjSi8O6Fw2xzEfFad5x0zpAtSAoVcSteoOFkTdZTSoiVuxqpz0hiw49GT2oVwZ0vqUWVZR1V8uAwZJww&_hsmi=417282505&utm_content=417282505&utm_source=hs_email In the remote areas of Yogyakarta, on the island of Java, tuberculosis (TB) runs rampant. Access to healthcare is scarce, and even when a clinic is available, doctors may be absent. As a result, individuals with the disease are often unnoticed, leading to a high transmission and mortality rate. Why is tuberculosis still a global challenge? A century after the first vaccine, tuberculosis still claims over a million lives a year, but promising research could change the story. https://www.drugdiscoverynews.com/why-is-tuberculosis-still-a-global-challenge-16811?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz--db_b0mhdqPrNsh185v0NR6pAGHy1h8AwRLLYXthBVhE684SGDD9NDfvA353ouiz6nBVHwrWbuAenwU7pvXLzjc89icg&_hsmi=417282505&utm_content=417282505&utm_source=hs_email In the US and UK, tuberculosis (TB) is a disease most people only encounter in history class. It is taught alongside the cholera epidemics of the 19th century, the Black Death, and the Spanish flu pandemic. It’s considered a disease of the past.