How an enzyme helps lung cancer survive radiation, and how to stop it Researchers identified a mitochondrial enzyme that shields lung cancer cells from a radiation-induced cell death process — and then found that an existing arthritis drug can disable that shield. Written byAndrea Corona

https://www.drugdiscoverynews.com/how-an-enzyme-helps-lung-cancer-survive-radiation-and-how-to-stop-it-17144?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-91vqyJZuy4gJIWMn0Hb45mQSZ5-nnAUxF-j1kIISeo5MLmxGgGYh6cQL2c8yT6OcMBf_h9DQkWTRfB7rYgM1FzHoht3A&_hsmi=420563864&utm_content=420563864&utm_source=hs_email Radiation therapy is among the most widely used treatments for lung cancer, but its effectiveness is frequently undermined by a familiar problem: Tumors that initially respond to treatment develop resistance and begin growing again. How exactly that resistance forms has remained incompletely understood, and the mechanisms that allow cancer cells to survive radiation-induced damage continue to be an active area of investigation.