False Positive mt-sDNA Tests Linked to Higher Rate of Aerodigestive Cancers Damian McNamara, MA May 11, 2026

https://www.medscape.com/viewarticle/false-positive-mt-sdna-tests-linked-higher-rate-2026a1000f3f CHICAGO — Once a multi-target stool DNA (mt-sDNA) test is identified as a false positive, it is often considered reassuring for patients and providers concerned about colorectal cancer. However, new research links these false positives to a small but significant increase in head and neck, lung, and gastric aerodigestive cancers, pointing to a need to further evaluate these patients.