A new design framework for mRNA vaccines could improve efficacy and safety

A new design framework for mRNA vaccines could improve efficacy and safety New findings suggest that the location of mRNA expression in the body plays a critical role in shaping T cell responses, opening the door to more precise and effective mRNA-based treatments. Written byBree Foster, PhD https://www.drugdiscoverynews.com/a-new-design-framework-for-mrna-vaccines-could-improve-efficacy-and-safety-17156 A new study from the Icahn School of Medicine at Mount Sinai challenges a central assumption in mRNA vaccine biology, showing that immune cells are not the only — or even the primary — determinant of vaccine effectiveness. Instead, non-immune cells such as muscle and liver cells play a previously underappreciated role in shaping immune responses, with major implications for mRNA vaccines and therapeutics.