Germline Testing in Breast Cancer (ASCO)

Germline Testing in Breast Cancer (ASCO) •Age criteria for BRCA1/2 testing Germline Testing in Breast Cancer Source: American Society of Clinical Oncology, Society of Surgical Oncology; Medically Reviewed by Dr Fharat Raja https://reference.medscape.com/cc2/p10/guideline-essentials-asco-sso-recommendations-germline-2025a10004h3?ecd=WNL_drugguide_260203_MSCPREF_onc_etid8073926&uac=148436CN&impID=8073926 In 2024, the American Society of Clinical Oncology (ASCO) and the Society of Surgical Oncology (SSO) published a guideline on germline testing in breast cancer. This Medscape guideline summary covers BRCA1/2 testing for newly diagnosed patients, those with recurrent disease or second primaries, and those with personal history but no active disease, as well as the value of testing for other predisposition genes and genetic counselling. Please refer to the full ASCO–SSO guideline for all recommendations, rationale, and background information. •Identifying cancer predisposition genes https://reference.medscape.com/cc2/p10/guideline-essentials-asco-sso-recommendations-germline-2025a10004h3?ecd=WNL_drugguide_260203_MSCPREF_onc_etid8073926&uac=148436CN&impID=8073926 •Managing variants of uncertain significance https://reference.medscape.com/cc2/p10/guideline-essentials-asco-sso-recommendations-germline-2025a10004h3?ecd=WNL_drugguide_260203_MSCPREF_onc_etid8073926&uac=148436CN&impID=8073926