Publication Date: Jul 23, 2020
Advanced Molecular Detection Clips Content
NEWS
- Civil War vaccination kits, discovered in a drawer, yield genetic clues to how smallpox was defeated
Cooney E. STAT, Jul 19, 2020. - The hunt for the origins of SARS-CoV-2 will look beyond China
Economist, Jul 22, 2020. - The mathematical strategy that could transform coronavirus testing
Mallapaty S. Nature, - The explosion of new coronavirus tests that could help to end the pandemic
Guglielmi G. Nature, Jul 17, 2020. - FDA gives green light on 'pool testing' to increase diagnostic capacity
Johnson M. The Hill, Jul 18, 2020. - U.S. must spend $75 billion to fix flawed Covid-19 testing, report says
Herper M. STAT, Jul 16, 2020. - Vaccine Race Is On: Oxford, China Products Show Good Early Results -- but population-specific efficacy questions remain as both progress to phase III
Walker M. MedPage Today, Jul 20, 2020.
POLICY
- Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States - The NIH RADx Initiative
Tromberg BJ, et al. New Engl J Med, Jul 22, 2020.
CONCEPTS / COMMENTS
- Research in the Context of a Pandemic.
Lane H Clifford et al. The New England journal of medicine 2020 Jul - COVID-19: from rapid genome sequencing to fast decisions.
Behrmann Ole et al. The Lancet. Infectious diseases 2020 Jul - Encouraging results from phase 1/2 COVID-19 vaccine trials
Bar-Zeev N, Moss WJ. Lancet, Jul 20, 2020. - Responsible, practical genomic data sharing that accelerates research.
Byrd James Brian et al. Nature reviews. Genetics 2020 Jul
METHODS / TOOLS
- Complete genome sequences of Streptococcus pyogenes type strain reveal 100%-match between PacBio-solo and Illumina-Oxford Nanopore hybrid assemblies.
Salvà-Serra Francisco et al. Scientific reports 2020 Jul (1) 11656 - Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses.
Gibson Keylie M et al. Viruses 2020 07 (7) - International external quality assessment for SARS-CoV-2 molecular detection and survey on clinical laboratory preparedness during the COVID-19 pandemic, April/May 2020.
Matheeussen Veerle et al. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2020 07 (27)
- Supporting pandemic response using genomics and bioinformatics: A case study on the emergent SARS-CoV-2 outbreak.
Bauer Denis C et al. Transboundary and emerging diseases 2020 Jul (4) 1453-1462 - SARS-CoV-2 encoded proteome and human genetics: from interaction-based to ribosomal biology impact on disease and risk processes.
Sirpilla Olivia et al. Journal of proteome research 2020 Jul - A unified catalog of 204,938 reference genomes from the human gut microbiome
Almeida A, et al. Nat Biotechnol, Jul 20, 2020.
EVOLUTION / ECOLOGY / POPULATIONS
- Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design.
Rice Alan M et al. Molecular biology and evolution 2020 Jul - Phylogenetic and phylodynamic analyses of SARS-CoV-2.
Nie Qing et al. Virus research 2020 Jul 198098 - Cocirculation of Swine H1N1 Influenza A Virus Lineages in Germany.
Zell Roland et al. Viruses 2020 Jul (7) - Population Genomic Structure and Recent Evolution of Plasmodium knowlesi, Peninsular Malaysia
Hocking SE, et al. Emerg Infect Dis, Aug 2020. - Population genomics of two invasive mosquitoes (Aedes aegypti and Aedes albopictus) from the Indo-Pacific.
Schmidt Thomas L et al. PLoS neglected tropical diseases 2020 Jul (7) e0008463
PATHOGENICITY / ANTIMICROBIAL RESISTANCE
- Horizontal Plasmid Transfer among Klebsiella pneumoniae Isolates Is the Key Factor for Dissemination of Extended-Spectrum β-Lactamases among Children in Tanzania.
Pedersen Torunn et al. mSphere 2020 Jul (4) - MOLECULAR MECHANISMS CONTRIBUTING TO FUZZY EPIDEMICS CAUSED BY GROUP A STREPTOCOCCUS, A FLESH-EATING HUMAN BACTERIAL PATHOGEN.
Musser James M et al. Transactions of the American Clinical and Climatological Association 2020 356-368 - A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance.
Goodman Christopher D et al. eLife 2020 Jul - Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study.
Imwong Mallika et al. The Lancet. Infectious diseases 2020 Jul
DETECTION / DIAGNOSIS
- Viability PCR shows that non-ocular surfaces could contribute to transmission of Chlamydia trachomatis infection in trachoma.
Versteeg Bart et al. PLoS neglected tropical diseases 2020 Jul (7) e0008449 - Application of artificial intelligence to the in silico assessment of antimicrobial resistance and risks to human and animal health presented by priority enteric bacterial pathogens.
Steinkey Rylan et al. Canada communicable disease report = Releve des maladies transmissibles au Canada 2020 Jun (6) 180-185 - Identification of SARS-CoV-2 in a Proficiency Testing Program.
Edson Daniel C et al. American journal of clinical pathology 2020 Jul - SARS-CoV-2 Titers in Wastewater Are Higher than Expected from Clinically Confirmed Cases.
Wu Fuqing et al. mSystems 2020 Jul (4) - Direct Observation of Repeated Infections With Endemic Coronaviruses.
Galanti Marta et al. The Journal of infectious diseases 2020 Jul - Environmental sampling for severe acute respiratory syndrome coronavirus 2 during COVID-19 outbreak in the Diamond Princess cruise ship.
Yamagishi Takuya et al. The Journal of infectious diseases 2020 Jul - SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts
Chirathaworn C, et al. bioRxiv, Jul 17, 2020. - Evolving viral and serological stages of Zika virus RNA-positive blood donors and estimation of incidence of infection during the 2016 Puerto Rican Zika epidemic: an observational cohort study.
Williamson Phillip C et al. The Lancet. Infectious diseases 2020 Jul
- Pre-treatment drug resistance and HIV-1 genetic diversity in the rural and urban settings of Northwest-Cameroon.
Fokam Joseph et al. PloS one 2020 (7) e0235958 - Advanced molecular surveillance approaches for characterization of blood borne hepatitis viruses.
Berg Michael G et al. PloS one 2020 (7) e0236046
EPIDEMIOLOGY / OUTBREAKS / TRANSMISSION
- Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands.
Oude Munnink Bas B et al. Nature medicine 2020 Jul - Detection and Genetic Characterization of Community-Based SARS-CoV-2 Infections - New York City, March 2020.
Bushman Dena et al. MMWR. Morbidity and mortality weekly report 2020 Jul (28) 918-922 - Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy
Alteri C, et al. medRxiv, Ju 20, 2020. - From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo
McAloose D, et al. bioRxiv, Jul 23, 2020. - Near Real-Time Identification of Recent HIV Transmissions, Transmitted Drug Resistance Mutations, and Transmission Networks by MPID-NGS in North Carolina.
Zhou Shuntai et al. The Journal of infectious diseases 2020 Jul
ANTIMICROBIALS / VACCINES / INTERVENTIONS
- The origins and genomic diversity of American Civil War Era smallpox vaccine strains.
Duggan Ana T et al. Genome biology 2020 Jul (1) 175 - A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C.
Napolitano Federico et al. PLoS neglected tropical diseases 2020 Jul (7) e0008459 - Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups.
Fisher Christine R et al. Cell reports 2020 Jul (3) 107920 - Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial
Zhu FC, et al. Lancet, Jul 20, 2020. - Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Folegatti PM, et al. Lancet, Jul 20, 2020.
HOST-MICROBE INTERACTIONS
- Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population.
Leal Diana Feio da Veiga Borges et al. PloS one 2020 (7) e0236033 - ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population.
Benetti Elisa et al. European journal of human genetics : EJHG 2020 Jul - The landscape of SARS-CoV-2 RNA modifications
Miladi M, et al. bioRxiv, Jul 18, 2020. - Epigenetic mechanisms regulating COVID-19 infection.
Chlamydas Sarantis et al. Epigenetics 2020 Jul - Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
Ellinghaus David et al. The New England journal of medicine 2020 Jun - ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
Torre-Fuentes Laura et al. Journal of medical virology 2020 Jul - Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19.
Lee Jeong Seok et al. Science immunology 2020 07 (49) - Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Hadjadj Jérôme et al. Science (New York, N.Y.) 2020 Jul - Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis.
Zhao Baihui et al. Scientific reports 2020 Jul (1) 11768
Note:
indicates that at least one CDC-affiliated author; indicates that the article addresses aspects of implementation or evaluation in clinical or public health practice.Disclaimer: Articles listed in the Advanced Molecular Detection Clips are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the clips does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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