Epidemiology, prevention and public health
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Multiple formin proteins participate in glioblastoma migration
The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look f...BMC Cancer 2020 20:710Liquid-based cytology for the detection of cervical intraepithelial lesions in Jimma town, Ethiopia
Cervical cancer is the second leading type of female cancer in Ethiopia. Screening for cervical cancer is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) is n...BMC Cancer 2020 20:706Associations between nutritional factors and KRAS mutations in colorectal cancer: a systematic review
Between 30 and 50% of colon tumors have mutations in the Kirsten-ras (KRAS) gene, which have a large nutritional attributable risk. Despite its high frequency in colorectal cancer (CRC), data to support specific ...BMC Cancer 2020 20:696Low dose environmental radon exposure and breast tumor gene expression
The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic mode...BMC Cancer 2020 20:695Cancer cases and deaths attributable to lifestyle risk factors in Chile
To identify modifiable risk factors that contribute to cancer holds important public health relevance for setting up prevention strategies. Therefore, the aim of this study was to estimate the proportion of ca...BMC Cancer 2020 20:693Risk stratified breast cancer screening: UK healthcare policy decision-making stakeholders’ views on a low-risk breast screening pathway
There is international interest in risk-stratification of breast screening programmes to allow women at higher risk to benefit from more frequent screening and chemoprevention. Risk-stratification also identif...BMC Cancer 2020 20:680Clinical characteristics and prognosis of anal squamous cell carcinoma: a retrospective audit of 144 patients from 11 cancer hospitals in southern China
The incidence of anal squamous cell carcinoma (SCC) has been steadily growing globally in the past decade. Clinical data on anal SCC from China are rare. We conducted this study to describe the clinical and ep...BMC Cancer 2020 20:679Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand
Targeted treatment with Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) is superior to systemic chemotherapy in non-small cell lung cancer (NSCLC) patients with EGFR gene mutations. Dete...BMC Cancer 2020 20:658Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study
Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase popul...BMC Cancer 2020 20:645Gynaecological cancer in Caribbean women: data from the French population-based cancer registries of Martinique, Guadeloupe and French Guiana (2007–2014)
For the first time, we present regional-level cancer incidence and world-standardized mortality rates for cancers for Martinique, Guadeloupe and French Guiana.BMC Cancer 2020 20:643Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis
Many studies have found that use of aspirin can lengthen survival in patients with gastrointestinal cancer. The aim of this study was to assess the survival benefit of aspirin use compared with non-aspirin use...BMC Cancer 2020 20:638Thyroid cancer in Ecuador
The incidence of thyroid cancer is increasing worldwide. This is not accompanied by a corresponding increase in mortality. In contrast, in most populations’ thyroid cancer mortality has been decreasing in rece...BMC Cancer 2020 20:637Head & neck acinar cell carcinoma: a population-based study using the seer registry
To explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively.BMC Cancer 2020 20:631Sarcoma epidemiology and cancer-related hospitalisation in Western Australia from 1982 to 2016: a descriptive study using linked administrative data
Sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Epidemiological studies on sarcoma from Australia are lacking, as previous studies have focused on a sarcoma type (e.g. soft t...BMC Cancer 2020 20:625Incidence, prevalence, mortality, and causes of death in Waldenström macroglobulinemia: a nationwide, population-based cohort study
The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. The goal of our study is to present the incidence, prevalence, m...BMC Cancer 2020 20:623Design and methods of a national, multicenter, randomized and controlled trial to assess the efficacy of a physical activity program to improve health-related quality of life and reduce fatigue in women with metastatic breast cancer: ABLE02 trial
Patients with a metastatic breast cancer suffer from a deteriorated health-related quality of life and numerous symptoms such as pain, severe fatigue and a decrease of their physical fitness. As the feasibilit...BMC Cancer 2020 20:622The impact on quality of life from informing diagnosis in patients with cancer: a systematic review and meta-analysis
The aim of this study was to assess the impact on quality of life from informing patients with cancer of their diagnosis and disease status.BMC Cancer 2020 20:618Cardio-toxicity among patients with sarcoma: a cardio-oncology registry
Chemotherapy induced cardio-toxicity has been recognized as a serious side effect since the first introduction to anthracyclines (ANT). Cardio-toxicity among patients with breast cancer is well studied but the...BMC Cancer 2020 20:609Body mass index increases the lymph node metastasis risk of breast cancer: a dose-response meta-analysis with 52904 subjects from 20 cohort studies
Since body mass index (BMI) is a convincing risk factor for breast cancer, it is speculated to be associated with lymph node metastasis. However, epidemiological studies are inconclusive. Therefore, this study...BMC Cancer 2020 20:601Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference
We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male p...BMC Cancer 2020 20:589What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420)
In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more fre...BMC Cancer 2020 20:570Cervical cancer screening in rural Ethiopia: a cross- sectional knowledge, attitude and practice study
Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This stu...BMC Cancer 2020 20:563Black patients referred to a lung cancer screening program experience lower rates of screening and longer time to follow-up
Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening...BMC Cancer 2020 20:561A prognostic nomogram for the cancer-specific survival of patients with upper-tract urothelial carcinoma based on the Surveillance, Epidemiology, and End Results Database
The aim of this study was to establish a comprehensive nomogram for the cancer-specific survival (CSS) of patients with upper-tract urothelial carcinoma (UTUC) and compare it with the traditional American Join...BMC Cancer 2020 20:534A novel nomogram to predict the reliability of estimated glomerular filtration rate formulae in oncology patients
Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agre...BMC Cancer 2020 20:530Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study
Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed ...BMC Cancer 2020 20:508Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis
Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico...BMC Cancer 2020 20:491A convenient clinical nomogram for predicting the cancer-specific survival of individual patients with small-intestine adenocarcinoma
The objective of this study was to develop a practical nomogram for predicting the cancer-specific survival (CSS) of patients with small-intestine adenocarcinoma.BMC Cancer 2020 20:505Performance of ultrasonography screening for breast cancer: a systematic review and meta-analysis
To investigate the performance of primary ultrasound (P-US) screening for breast cancer, and that of supplemental ultrasound (S-US) screening for breast cancer after negative mammography (MAM).BMC Cancer 2020 20:499Augmenting cancer registry data with health survey data with no cases in common: the relationship between pre-diagnosis health behaviour and post-diagnosis survival in oesophageal cancer
For epidemiological research, cancer registry datasets often need to be augmented with additional data. Data linkage is not feasible when there are no cases in common between data sets. We present a novel appr...BMC Cancer 2020 20:496Patient and tumour characteristics associated with inclusion in Cancer patient pathways in Norway in 2015–2016
Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study we...BMC Cancer 2020 20:488A scientometric analysis of neuroblastoma research
Thousands of research articles on neuroblastoma have been published over the past few decades; however, the heterogeneity and variable quality of scholarly data may challenge scientists or clinicians to survey...BMC Cancer 2020 20:486Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study
Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asian...BMC Cancer 2020 20:479Knowledge, attitudes and practices of South Asian immigrants in developed countries regarding oral cancer: an integrative review
Oral cancer is a growing problem worldwide, with high incidence rates in South Asian countries. With increasing numbers of South Asian immigrants in developed countries, a possible rise in oral cancer cases is...BMC Cancer 2020 20:477Cancer staging in individuals with a severe psychiatric illness: a cross-sectional study using population-based cancer registry data
Advanced cancer stage at diagnosis may explain high cancer mortality among patients with a severe psychiatric illness (SPI). Studies to date investigating advanced stage cancer at diagnosis as a potential expl...BMC Cancer 2020 20:476Elderly women’s experiences of self-sampling for HPV testing
Self-sampling for HPV testing, as an alternative to the conventional speculum based sampling, is highly acceptable to women of screening ages. The aim of this study was to describe older women’s (60 to 75 year...BMC Cancer 2020 20:473Combination of preoperative neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio: a superior prognostic factor of endometrial cancer
The preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) have been reported to be associated with the prognosis of various cancer...BMC Cancer 2020 20:464Could venous thromboembolism and major bleeding be indicators of lung cancer mortality? A nationwide database study
Venous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to eval...BMC Cancer 2020 20:461Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study
Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have ...BMC Cancer 2020 20:460Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis
Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TAT...BMC Cancer 2020 20:454The introduction of risk stratified screening into the NHS breast screening Programme: views from British-Pakistani women
UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to ide...BMC Cancer 2020 20:452The role of human papillomavirus genotyping for detecting high-grade intraepithelial neoplasia or cancer in HPV-positive women with normal cytology: a study from a hospital in northeastern China
Human papillomavirus (HPV) testing is more sensitive than cytology for detecting cervical cancer and its precursors. This study aimed to analyze the prevalence of high-risk HPV genotypes and evaluate the role ...BMC Cancer 2020 20:443A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma
Adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer. The purpose of this study was to assess the cumulative incidences of lung cancer-specific mortality (LC-SM) and other cause-spe...BMC Cancer 2020 20:429Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates
Tuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown.BMC Cancer 2020 20:412Are cancer patients better off if they participate in clinical trials? A mixed methods study
Research and cancer care are closely intertwined; however, it is not clear whether physicians and nurses believe that clinical trials offer the best treatment for patients and, if so, whether this belief is ju...BMC Cancer 2020 20:401Clinical validation of full genotyping CLART® HPV4S assay on SurePath and ThinPrep collected screening samples according to the international guidelines for human papillomavirus test requirements for cervical screening
To ensure the highest quality of human papillomavirus (HPV) testing in primary cervical cancer screening, novel HPV assays must be evaluated in accordance with the international guidelines. Furthermore, HPV as...BMC Cancer 2020 20:396Impact of the comprehensive geriatric assessment on treatment decision in geriatric oncology
The comprehensive geriatric assessment (CGA) is the gold standard in geriatric oncology to identify patients at high risk of adverse outcomes and optimize cancer and overall management. Many studies have demon...BMC Cancer 2020 20:384Inferring the role of the microbiome on survival in patients treated with immune checkpoint inhibitors: causal modeling, timing, and classes of concomitant medications
The microbiome has been shown to affect the response to Immune Checkpoint Inhibitors (ICIs) in a small number of cancers and in preclinical models. Here, we sought to broadly survey cancers to identify those i...BMC Cancer 2020 20:383Moderate to vigorous physical activity participation associated with better quality of life among breast and colorectal cancer survivors in Korea
To investigate the association between physical activity (PA) and quality of life (QoL) among breast and colorectal cancer survivors in Korea.BMC Cancer 2020 20:365Higher number of multidisciplinary tumor board meetings per case leads to improved clinical outcome
This analysis aims at evaluating the impact of multidisciplinary tumor boards on clinical outcome of multiple tumor entities, the effect of the specific number of multidisciplinary tumor boards and potential d...BMC Cancer 2020 20:355
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