Platelet hyperreactivity, a unique feature of COVID-19
Over 16.6 million people have been infected the world over with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since the COVID-19 outbreak began in December 2020. The infection is a curious one, with many scientists comparing the confirmed cases to the tip of an iceberg.
Among the vexing uncertainties of the disease is the difficulty of predicting which patient will develop progressive severe symptoms ending in respiratory failure and death. COVID-19 disease, caused by the virus, is marked by a hyperinflammatory response and severe pneumonitis. Prior research has indicated that this inflammatory pathway interacts with abnormal coagulation activity, and this is a driver of severe illness in these patients.
Now, a new study by Irish researchers and published in the preprint server medRxiv* in July 2020 reports a bidirectional relationship between COVID-19 and coagulation abnormalities.
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