Sleep and Memory: The Promise of Precision Medicine.

Carter P1, Ye L2, Richards K3, Vallabhaneni V4.

Author information

1: School of Nursing, University of Texas at Austin, 1710 Red River Street, Austin, TX 78712, USA. Electronic address: pcarter@mail.nur.texas.edu.
2: School of Nursing, Bouve College of Health Sciences, Northeastern University, 207c Robinson Hall, 360 Huntington Avenue, Boston, MA 02115, USA.
3: School of Nursing, University of Texas at Austin, 1710 Red River Street, Austin, TX 78712, USA.
4: Texas A&M University, Sleep 360 Sleep Diagnostic Center, 10601 Pecan Park boulevard, Ste 203, Austin, TX 78750, USA.

Abstract

Given the complex and bidirectional nature of sleep and mild cognitive impairment/Alzheimer's disease and related dementias, a precision medicine approach to education, lifestyle changes, and early assessment in patients with a family history of snoring, sleep apnea, diabetes, and heart disease is warranted. Furthermore, a team-based approach allows for a coordinated precision diagnosis and management of common comorbid chronic illnesses. The significance of sleep disturbances in this population, contributing factors, assessment and diagnostic challenges, common sleep disorders and mechanisms, tailored behavioral and pharmacologic interventions, knowledge gaps, and future research ideas are discussed.

KEYWORDS:

Alzheimer’s disease and related dementias (ADRD); Elderly; Mild cognitive impairment (MCI); Precision sleep assessment; Precision sleep treatment; Sleep