Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.

Högl B1, Santamaria J2, Iranzo A2, Stefani A3.

Author information

1: Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria.
2: Neurology Service, Multidisciplinary Sleep Unit, Hospital Clinic de Barcelona, Institut D'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Calle Villarroel, 170, Barcelona 08036, Spain.
3: Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria. Electronic address: ambra.stefani@i-med.ac.at.

Abstract

In recent years, the diagnostic approach to rapid eye movement (REM) sleep behavior disorder (RBD) has become more objective and accurate. This was achieved mainly by introduction of methods to exactly quantify electromyographic (EMG) activity in various muscles during REM sleep. The most established muscle combination for RBD diagnosis is the mentalis and upper extremity EMG. Computer-assisted systems for this analysis have been described, and an increasing number of studies looked into analysis of video events. Recently, prodromal phases of isolated RBD have been recognized.