Non-REM Parasomnia: The Promise of Precision Medicine.

Author information

1: Department of Neurology, University of North Carolina, Chapel Hill, University of North Carolina School of Medicine, CB#7025, Chapel Hill, NC 27599-7025, USA.
2: Department of Neurology, University of North Carolina, Chapel Hill, University of North Carolina School of Medicine, CB#7025, Chapel Hill, NC 27599-7025, USA. Electronic address: vaughnb@neurology.unc.edu.

Abstract

Our understanding of non-REM parasomnias is just beginning to unfold the potential biomarkers and underlying pathophysiologic processes that lead to these events. Biomarkers need further investigation and will help us to understand better ways to develop risk models and possible mechanisms. Similarly, as we develop more accurate pathophysiologic-based diagnostic testing for non-REM parasomnias, we will begin the evolution toward a physiologic-based classification scheme that aids the application of precision medicine. This article explores currently known characteristics and exploratory features that may aid in this transition to better understanding our individual patients with non-REM parasomnias and tailoring their treatments.